000002724 001__ 2724
000002724 005__ 20260120144901.0
000002724 0247_ $$2DOI$$a10.6083/M46T0JZ4
000002724 037__ $$aETD
000002724 245__ $$aProgramming of the fetal hematopoietic stem and progenitor cell compartment
000002724 269__ $$a2013
000002724 336__ $$aDissertation
000002724 502__ $$bPh.D.
000002724 502__ $$gCell & Developmental Biology (sunsetting)
000002724 520__ $$aDevelopmental origins of disease in the hematopoietic system remain poorly understood despite rising pediatric hematologic and immune disorders. Fanconi anemia (FA), the most common inherited bone marrow failure syndrome, is traditionally attributed to postnatal stem cell loss. Using Fancc-deficient mouse models, we demonstrate a prenatal deficit in fetal liver hematopoietic stem and progenitor cells (HSPCs), including reduced repopulating capacity and cell cycle arrest. Increased γH2AX foci and upregulation of DNA repair genes indicate heightened susceptibility to DNA damage absent external stressors. These findings suggest congenital defects in hematopoiesis contribute to FA pathogenesis, highlighting the fetal hematopoietic compartment as a critical target.
000002724 540__ $$fCC BY
000002724 542__ $$fIn copyright - single owner
000002724 650__ $$aFetal Development$$035918
000002724 650__ $$aHematopoietic Stem Cells$$020016
000002724 650__ $$aFanconi Anemia$$018886
000002724 650__ $$aObesity$$023118
000002724 650__ $$aCongenital Bone Marrow Failure Syndromes$$013196
000002724 650__ $$aChild$$016462
000002724 650__ $$aHematopoietic System$$020017
000002724 650__ $$aDiet, High-Fat$$039538
000002724 691__ $$aSchool of Medicine$$041369
000002724 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000002724 7001_ $$aKamimae-Lanning, Ashley$$uOregon Health and Science University$$041354
000002724 7201_ $$aKurre, Peter$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000002724 8564_ $$93e5fa659-bbfa-4116-8020-fd25ee6f5413$$s1979336$$uhttps://digitalcollections.ohsu.edu/record/2724/files/3465_etd.pdf$$ePublic$$29df50840c50acd36c8ca4ddcce3c98e4$$31
000002724 905__ $$a/rest/prod/j9/60/20/75/j96020756
000002724 909CO $$ooai:digitalcollections.ohsu.edu:2724$$pstudent-work
000002724 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002724 980__ $$aTheses and Dissertations