TY  - GEN
AB  - Cranial placodes are transient ectodermal structures that give rise to key sensory organs and neurons in the vertebrate head. This dissertation investigates the molecular and cellular mechanisms governing the specification and segregation of otic and epibranchial (EB) placodes in zebrafish. Using lineage tracing, live imaging, and functional assays, we show that Pax2a expression levels bias cell fate toward otic or EB identities, with Wnt signaling enforcing otic specification. Continuous Fgf signaling, particularly from Fgf3 and Fgf10a, is required for EB placode maturation, with distinct tissue sources identified for these ligands. These findings provide new insights into sensory organ development and early neural progenitor specification outside the CNS.
AD  - Oregon Health and Science University
AU  - McCarroll, Matthew
DA  - 2014
DO  - 10.6083/M4NV9GK5
DO  - DOI
ED  - Nechiporuk, Alex
ED  - Advisor
ED  - Mentor
ID  - 2736
KW  - Ganglia
KW  - Fibroblast Growth Factors
KW  - Sense Organs
KW  - Developmental Biology
KW  - Signal Transduction
KW  - Neurogenesis
L1  - https://digitalcollections.ohsu.edu/record/2736/files/3524_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2736/files/3524_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2736/files/3524_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2736/files/3524_etd.pdf
N2  - Cranial placodes are transient ectodermal structures that give rise to key sensory organs and neurons in the vertebrate head. This dissertation investigates the molecular and cellular mechanisms governing the specification and segregation of otic and epibranchial (EB) placodes in zebrafish. Using lineage tracing, live imaging, and functional assays, we show that Pax2a expression levels bias cell fate toward otic or EB identities, with Wnt signaling enforcing otic specification. Continuous Fgf signaling, particularly from Fgf3 and Fgf10a, is required for EB placode maturation, with distinct tissue sources identified for these ligands. These findings provide new insights into sensory organ development and early neural progenitor specification outside the CNS.
PB  - Oregon Health and Science University
PY  - 2014
T1  - Origin of cranial sensory systems
TI  - Origin of cranial sensory systems
UR  - https://digitalcollections.ohsu.edu/record/2736/files/3524_etd.pdf
Y1  - 2014
ER  -