000002736 001__ 2736
000002736 005__ 20260120144901.0
000002736 0247_ $$2DOI$$a10.6083/M4NV9GK5
000002736 037__ $$aETD
000002736 245__ $$aOrigin of cranial sensory systems
000002736 260__ $$bOregon Health and Science University
000002736 269__ $$a2014
000002736 336__ $$aDissertation
000002736 502__ $$bPh.D.
000002736 520__ $$aCranial placodes are transient ectodermal structures that give rise to key sensory organs and neurons in the vertebrate head. This dissertation investigates the molecular and cellular mechanisms governing the specification and segregation of otic and epibranchial (EB) placodes in zebrafish. Using lineage tracing, live imaging, and functional assays, we show that Pax2a expression levels bias cell fate toward otic or EB identities, with Wnt signaling enforcing otic specification. Continuous Fgf signaling, particularly from Fgf3 and Fgf10a, is required for EB placode maturation, with distinct tissue sources identified for these ligands. These findings provide new insights into sensory organ development and early neural progenitor specification outside the CNS.
000002736 540__ $$fCC BY
000002736 542__ $$fIn copyright - single owner
000002736 650__ $$aGanglia$$019377
000002736 650__ $$aFibroblast Growth Factors$$019019
000002736 650__ $$aSense Organs$$025870
000002736 650__ $$aDevelopmental Biology$$028463
000002736 650__ $$aSignal Transduction$$028380
000002736 650__ $$aNeurogenesis$$038327
000002736 691__ $$aSchool of Medicine$$041369
000002736 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000002736 7001_ $$aMcCarroll, Matthew$$uOregon Health and Science University$$041354
000002736 7201_ $$aNechiporuk, Alex$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000002736 8564_ $$9462241b2-1d1f-4638-afb3-3dc4e279774a$$s68319093$$uhttps://digitalcollections.ohsu.edu/record/2736/files/3524_etd.pdf$$ePublic$$2c131ae3f209e6b2011189ef83a7ca4b4$$31
000002736 905__ $$a/rest/prod/1c/18/df/95/1c18df959
000002736 909CO $$ooai:digitalcollections.ohsu.edu:2736$$pstudent-work
000002736 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002736 980__ $$aTheses and Dissertations