000002737 001__ 2737
000002737 005__ 20250424232751.0
000002737 0247_ $$2DOI$$a10.6083/M4J38QVR
000002737 037__ $$aETD
000002737 245__ $$aConnecting genotypes to drug sensitivities in HER2 positive cancer cell lines
000002737 260__ $$bOregon Health and Science University
000002737 269__ $$a2014
000002737 336__ $$aDissertation
000002737 502__ $$bPh.D.
000002737 520__ $$aHER2-positive breast cancer is an aggressive subtype of breast cancer with patients having significantly lower survival rates compared to other breast cancers. HER2-positive breast cancer shows pathway addiction to multiple mitogenic signaling pathways. One strategy in cancer treatment is targeted drug therapy which inhibits the function of specific proteins along these signaling pathways Predicting drug sensitivity using a patient's tumor markers such as somatic mutations and copy number variation can help guide treatment selection toward the realization of precision medicine. The motivation for this work is to 1) characterize the degree of cross-phenotype response when a targeted inhibitor is applied and 2) identify potential oncogene collaborations that can drive the decisions of which targeted treatments should be used.
000002737 540__ $$fCC BY
000002737 542__ $$fIn copyright - single owner
000002737 650__ $$aCell Line$$016284
000002737 650__ $$aComputational Biology$$031511
000002737 650__ $$aCarcinogenesis$$040251
000002737 650__ $$aSystems Biology$$036214
000002737 650__ $$aProteomics$$035059
000002737 650__ $$aSurvival Rate$$028805
000002737 650__ $$aDNA Copy Number Variations$$038765
000002737 650__ $$aPrecision Medicine$$038927
000002737 650__ $$aBiomarkers, Tumor$$027501
000002737 650__ $$aBreast Neoplasms$$015809
000002737 691__ $$aSchool of Medicine$$041369
000002737 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000002737 7001_ $$aLaderas, Ted$$uOregon Health and Science University$$041354
000002737 7201_ $$aSonmez, Kemal$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000002737 8564_ $$9ec2e5986-a724-4475-b8f1-d9997b04fd99$$s7005099$$uhttps://digitalcollections.ohsu.edu/record/2737/files/3523_etd.pdf$$ePublic$$2f898b3aaa952cc38a372d1b7329a67c5$$31
000002737 905__ $$a/rest/prod/kk/91/fk/70/kk91fk708
000002737 909CO $$ooai:digitalcollections.ohsu.edu:2737$$pstudent-work
000002737 980__ $$aBiomedical Informatics