TY  - GEN
AB  - Alcohol use disorders (AUDs) are complex conditions with no single animal model capturing all aspects of the disease. This dissertation examines the effects of the neuroactive steroid analog ganaxolone (GAN) on ethanol seeking and intake in male C57BL/6J mice, alongside gaboxadol (THIP), an agonist selective for extrasynaptic GABAA_AA​ receptors. Findings aim to clarify the role of synaptic versus extrasynaptic GABAA_AA​ receptor activation in modulating ethanol-related behaviors and identify the nucleus accumbens shell as a potential neural substrate for these effects.
AD  - Oregon Health and Science University
AU  - Ramaker, Marcia
DA  - 2014
DO  - 10.6083/M48K77CN
DO  - DOI
ED  - Finn, Deborah
ED  - Mentor
ID  - 2739
KW  - Ethanol
KW  - Isoxazoles
KW  - Alcohol-Related Disorders
KW  - Pregnanolone
KW  - gamma-Aminobutyric Acid
KW  - Neurosteroids
KW  - Mice, Inbred C57BL
KW  - Alcoholism
KW  - Mice
KW  - Alcohol Drinking
L1  - https://digitalcollections.ohsu.edu/record/2739/files/3521_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2739/files/3521_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2739/files/3521_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2739/files/3521_etd.pdf
N2  - Alcohol use disorders (AUDs) are complex conditions with no single animal model capturing all aspects of the disease. This dissertation examines the effects of the neuroactive steroid analog ganaxolone (GAN) on ethanol seeking and intake in male C57BL/6J mice, alongside gaboxadol (THIP), an agonist selective for extrasynaptic GABAA_AA​ receptors. Findings aim to clarify the role of synaptic versus extrasynaptic GABAA_AA​ receptor activation in modulating ethanol-related behaviors and identify the nucleus accumbens shell as a potential neural substrate for these effects.
PB  - Oregon Health and Science University
PY  - 2014
T1  - The effect of a neuroactive steroid analog and an extrasynaptic GABAA receptor agonist on ethanol consumption and seeking in mice
TI  - The effect of a neuroactive steroid analog and an extrasynaptic GABAA receptor agonist on ethanol consumption and seeking in mice
UR  - https://digitalcollections.ohsu.edu/record/2739/files/3521_etd.pdf
Y1  - 2014
ER  -