000002739 001__ 2739
000002739 005__ 20251204142528.0
000002739 0247_ $$2DOI$$a10.6083/M48K77CN
000002739 037__ $$aETD
000002739 245__ $$aThe effect of a neuroactive steroid analog and an extrasynaptic GABAA receptor agonist on ethanol consumption and seeking in mice
000002739 260__ $$bOregon Health and Science University
000002739 269__ $$a2014
000002739 336__ $$aDissertation
000002739 502__ $$bPh.D.
000002739 502__ $$gBehavioral Neuroscience
000002739 520__ $$aAlcohol use disorders (AUDs) are complex conditions with no single animal model capturing all aspects of the disease. This dissertation examines the effects of the neuroactive steroid analog ganaxolone (GAN) on ethanol seeking and intake in male C57BL/6J mice, alongside gaboxadol (THIP), an agonist selective for extrasynaptic GABAA_AA​ receptors. Findings aim to clarify the role of synaptic versus extrasynaptic GABAA_AA​ receptor activation in modulating ethanol-related behaviors and identify the nucleus accumbens shell as a potential neural substrate for these effects.
000002739 540__ $$fCC BY
000002739 542__ $$fIn copyright - single owner
000002739 650__ $$aEthanol$$014406
000002739 650__ $$aIsoxazoles$$021089
000002739 650__ $$aAlcohol-Related Disorders$$032034
000002739 650__ $$aPregnanolone$$024553
000002739 650__ $$agamma-Aminobutyric Acid$$019337
000002739 650__ $$aNeurosteroids$$013246
000002739 650__ $$aMice, Inbred C57BL$$022241
000002739 650__ $$aAlcoholism$$014412
000002739 650__ $$aMice$$036842
000002739 650__ $$aAlcohol Drinking$$014403
000002739 691__ $$aSchool of Medicine$$041369
000002739 692__ $$aDepartment of Behavioral Neuroscience$$041394
000002739 7001_ $$aRamaker, Marcia$$uOregon Health and Science University$$041354
000002739 7201_ $$aFinn, Deborah$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000002739 8564_ $$98331fa59-0283-43e1-8fdb-cc4d3f83e18d$$s3711123$$uhttps://digitalcollections.ohsu.edu/record/2739/files/3521_etd.pdf$$ePublic$$2373cf8bce307d74a49b877a5c0786533$$31
000002739 905__ $$a/rest/prod/qf/85/nb/50/qf85nb50p
000002739 909CO $$ooai:digitalcollections.ohsu.edu:2739$$pstudent-work
000002739 980__ $$aTheses and Dissertations