000002742 001__ 2742
000002742 005__ 20260120144901.0
000002742 0247_ $$2DOI$$a10.6083/M4513WXQ
000002742 037__ $$aETD
000002742 245__ $$aThe role of dopamine D1/5 receptors in fear and reward
000002742 269__ $$a2014
000002742 336__ $$aDissertation
000002742 502__ $$bPh.D.
000002742 502__ $$gBehavioral & Systems Neuroscience
000002742 520__ $$aExtinction learning, which inhibits conditioned stimulus–unconditioned stimulus associations, is influenced by dopamine signaling and has clinical relevance for disorders such as PTSD and addiction. This dissertation examines the role of dopamine D1/5 receptors in fear and reward extinction using pharmacological manipulations, knockout models, and intracranial microinjections. Findings show that methylphenidate and D1/5 receptor agonist SKF 81297 enhance fear extinction and cocaine reward extinction, while D1 receptor knockout alters fear expression without impairing acquisition. Mechanistic studies implicate PKA-coupled D1/5 receptor signaling in extinction enhancement. Results suggest dopamine signaling contributes to extinction processes and may inform therapeutic strategies.
000002742 540__ $$fCC BY
000002742 542__ $$fIn copyright - single owner
000002742 650__ $$aReward$$025422
000002742 650__ $$aLearning$$021358
000002742 650__ $$aMemory$$022012
000002742 650__ $$aFear$$018921
000002742 650__ $$aDopamine$$018026
000002742 650__ $$aReceptors, Dopamine D1$$029976
000002742 650__ $$aExtinction, Psychological$$018795
000002742 691__ $$aSchool of Medicine$$041369
000002742 692__ $$aDepartment of Behavioral Neuroscience$$041394
000002742 7001_ $$aAbraham, Antony$$uOregon Health and Science University$$041354
000002742 7201_ $$aLattal, Matt$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000002742 8564_ $$9e434c928-f523-4918-aadb-d27f3c2d0670$$s3567431$$uhttps://digitalcollections.ohsu.edu/record/2742/files/3518_etd.pdf$$ePublic$$28976b1a43e33b64e37ca03810dbbf06f$$31
000002742 905__ $$a/rest/prod/n2/96/wz/34/n296wz34n
000002742 909CO $$ooai:digitalcollections.ohsu.edu:2742$$pstudent-work
000002742 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002742 980__ $$aTheses and Dissertations