TY - GEN AB - Extinction is a complex period of learning during which a predicted relationship between stimuli (i.e. conditioned stimulus-unconditioned stimulus association) is inhibited by presentation of the predictive stimulus alone (i.e. non- reinforced conditioned stimulus), and this learning can be impaired by blockade of dopamine receptor activity. Thus, examining the relationship between dopamine and extinction may be beneficial to understanding basic features of learning and memory. Furthermore, enhancing extinction may be beneficial at a clinical level, as impaired extinction is hypothesized to contribute to a number of diseases of learning and memory, such as posttraumatic stress disorder and substance use disorders. The overarching goal of this dissertation is to examine the consequence of altering dopamine signaling during acquisition and extinction of fear and reward to specify the contribution of dopamine signaling within these particular phases of learning. AD - Oregon Health and Science University AU - Akeroyd, Jennifer DA - 2014 DO - 10.6083/M4RV0MD3 DO - DOI ED - Lattal, Matthew ED - Advisor ID - 2743 KW - Environment KW - Cooperative Behavior KW - Transportation KW - Environmental Policy KW - Health Personnel KW - Motor Activity KW - Reward KW - Fear KW - Substance-Related Disorders KW - Dopamine KW - Receptors, Dopamine KW - Stress Disorders, Post-Traumatic L1 - https://digitalcollections.ohsu.edu/record/2743/files/3517_etd.pdf L2 - https://digitalcollections.ohsu.edu/record/2743/files/3517_etd.pdf L4 - https://digitalcollections.ohsu.edu/record/2743/files/3517_etd.pdf LK - https://digitalcollections.ohsu.edu/record/2743/files/3517_etd.pdf N2 - Extinction is a complex period of learning during which a predicted relationship between stimuli (i.e. conditioned stimulus-unconditioned stimulus association) is inhibited by presentation of the predictive stimulus alone (i.e. non- reinforced conditioned stimulus), and this learning can be impaired by blockade of dopamine receptor activity. Thus, examining the relationship between dopamine and extinction may be beneficial to understanding basic features of learning and memory. Furthermore, enhancing extinction may be beneficial at a clinical level, as impaired extinction is hypothesized to contribute to a number of diseases of learning and memory, such as posttraumatic stress disorder and substance use disorders. The overarching goal of this dissertation is to examine the consequence of altering dopamine signaling during acquisition and extinction of fear and reward to specify the contribution of dopamine signaling within these particular phases of learning. PY - 2014 T1 - Cross-sector collaboration to increase active transportation: a grounded theory from the health sector perspective TI - Cross-sector collaboration to increase active transportation: a grounded theory from the health sector perspective UR - https://digitalcollections.ohsu.edu/record/2743/files/3517_etd.pdf Y1 - 2014 ER -