000002753 001__ 2753
000002753 005__ 20251204143217.0
000002753 0247_ $$2DOI$$a10.6083/M4F76B88
000002753 037__ $$aETD
000002753 245__ $$aThe effects of nicotine and varenicline on ethanol reward and neuroadaptation
000002753 260__ $$bOregon Health and Science University
000002753 269__ $$a2014
000002753 336__ $$aDissertation
000002753 502__ $$bPh.D.
000002753 502__ $$gBehavioral & Systems Neuroscience
000002753 520__ $$aNicotine and ethanol are frequently co-abused, yet the mechanisms underlying this association remain unclear. This dissertation examined combined versus independent effects of nicotine and ethanol on locomotor stimulation, conditioned place preference (CPP), sensitization, and nicotinic receptor regulation in mice. Nicotine enhanced ethanol-induced stimulation in ethanol-sensitive genotypes but did not increase ethanol reward or alter nAChR density. Combined drug effects on sensitization were dose-dependent and context-specific. Additionally, varenicline, a partial nAChR agonist, attenuated ethanol-induced stimulation and expression of sensitization but not CPP, suggesting its potential to reduce acute and neuroadaptive ethanol effects without impacting cue-related behaviors.
000002753 540__ $$fCC BY
000002753 542__ $$fIn copyright - single owner
000002753 650__ $$aNicotine$$022904
000002753 650__ $$aEthanol$$014406
000002753 650__ $$aNicotinic Agonists$$031041
000002753 650__ $$aMice$$036842
000002753 650__ $$aTobacco Use Cessation Devices$$039946
000002753 691__ $$aSchool of Medicine$$041369
000002753 692__ $$aDepartment of Behavioral Neuroscience$$041394
000002753 7001_ $$aGubner, Noah$$uOregon Health and Science University$$041354
000002753 7201_ $$aPhillips, Tamara$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000002753 8564_ $$9a4f1dfc3-875a-4803-aaf7-8e4be3ae90c0$$s3257077$$uhttps://digitalcollections.ohsu.edu/record/2753/files/3507_etd.pdf$$ePublic$$20f88f62c287c2971c0018d516e190201$$31
000002753 905__ $$a/rest/prod/0r/96/73/95/0r967395n
000002753 909CO $$ooai:digitalcollections.ohsu.edu:2753$$pstudent-work
000002753 980__ $$aTheses and Dissertations