000002754 001__ 2754
000002754 005__ 20260120144901.0
000002754 0247_ $$2DOI$$a10.6083/M49G5KH3
000002754 037__ $$aETD
000002754 245__ $$aAssociation between longitudinal changes in gait speed and survival time in aging men: a joint longitudinal and time-to-event analysis of data from MrOS study
000002754 269__ $$a2014
000002754 336__ $$aThesis
000002754 502__ $$bM.S.
000002754 502__ $$gBiostatistics
000002754 520__ $$aSlower gait speed has previously been shown to be associated with mortality in aging pop- ulations, based on a single measure of gait speed,1–3 but repeated measures of gait speed may be more informative. Although an extended Cox model can accommodate a time- varying covariate, the Cox framework has certain limitations in context of endogenous or continuous time-varying covariates or time-varying covariates measured with error. The joint modeling framework uses a smooth, continuous model of the time-varying co- variate that may more accurately represent its true, underlying longitudinal trajectory. The objective of this thesis is to estimate the association between longitudinal trajectories of gait speed and survival time and to compare estimates of association from separate models (i.e., mixed-effects models and Cox models) and joint models.
000002754 540__ $$fCC BY
000002754 542__ $$fIn copyright - single owner
000002754 650__ $$aSurvival$$026674
000002754 650__ $$aSurvival Analysis$$028823
000002754 650__ $$aWalking$$028911
000002754 650__ $$aAging$$014358
000002754 650__ $$aLongitudinal Studies$$021617
000002754 650__ $$aWalking Speed$$012095
000002754 650__ $$aProportional Hazards Models$$028820
000002754 6531_ $$astatistics and numerical data
000002754 691__ $$aSchool of Medicine$$041369
000002754 692__ $$aDepartment of Public Health and Preventive Medicine$$041444
000002754 7001_ $$aHart, Kyle$$uOregon Health and Science University$$041354
000002754 7201_ $$aLapidus, Jodi$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000002754 8564_ $$923d83fdc-99b2-4846-a763-ec98a9cd61d4$$s1542278$$uhttps://digitalcollections.ohsu.edu/record/2754/files/3506_etd.pdf$$ePublic$$2eea290403d396fca8fa1b80f93f1414b$$31
000002754 905__ $$a/rest/prod/cr/56/n1/20/cr56n1206
000002754 909CO $$ooai:digitalcollections.ohsu.edu:2754$$pstudent-work
000002754 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002754 980__ $$aTheses and Dissertations