000002766 001__ 2766
000002766 005__ 20260120144901.0
000002766 0247_ $$2DOI$$a10.6083/M4W957WF
000002766 037__ $$aETD
000002766 245__ $$aUnderstanding the placebo response in neuropathic pain drug treatment trials
000002766 260__ $$bOregon Health and Science University
000002766 269__ $$a2014
000002766 336__ $$aThesis
000002766 502__ $$bM.P.H.
000002766 502__ $$gEpidemiology
000002766 502__ $$gBiostatistics
000002766 520__ $$aPlacebo response variability in neuropathic pain trials complicates indirect comparisons of pharmacotherapies. This meta-regression analysis of 39 randomized placebo-controlled trials identified predictors of placebo response and treatment effect after adjustment for placebo. Key predictors included dosing flexibility, baseline pain, gender distribution, and diagnosis of painful diabetic neuropathy. After controlling for placebo response, longer treatment duration was inversely associated with treatment effect and explained most between-study variance in sensitivity analyses. Findings highlight the need for standardized trial designs and consideration of placebo-related factors in systematic reviews and meta-analyses to improve interpretation and generalizability of neuropathic pain treatment evidence.
000002766 540__ $$fCC BY
000002766 542__ $$fIn copyright - single owner
000002766 650__ $$aPlacebos$$024209
000002766 650__ $$aPlacebo Effect$$028799
000002766 650__ $$aNeuralgia$$022822
000002766 650__ $$aDiabetic Neuropathies$$017680
000002766 692__ $$aDepartment of Public Health and Preventive Medicine$$041444
000002766 7001_ $$aSelph, Shelley$$uOregon Health and Science University$$041354
000002766 7201_ $$aLambert, William$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000002766 8564_ $$955e0f420-0712-43bc-a50d-d13eb7ecc6d3$$s915038$$uhttps://digitalcollections.ohsu.edu/record/2766/files/3535_etd.pdf$$ePublic$$2c1c61976f9304832494678ed6144cd5a$$31
000002766 905__ $$a/rest/prod/66/82/x4/12/6682x4120
000002766 909CO $$ooai:digitalcollections.ohsu.edu:2766$$pstudent-work
000002766 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002766 980__ $$aTheses and Dissertations