000002771 001__ 2771
000002771 005__ 20251204133641.0
000002771 0247_ $$2DOI$$a10.6083/M4C82802
000002771 037__ $$aETD
000002771 245__ $$aTFR2, HFE, and HJV in the regulation of body iron homeostasis
000002771 260__ $$bOregon Health and Science University
000002771 269__ $$a2014
000002771 336__ $$aDissertation
000002771 502__ $$bPh.D.
000002771 502__ $$gCell & Developmental Biology (sunsetting)
000002771 520__ $$aIron homeostasis is tightly regulated to balance essential physiological functions with the risk of iron toxicity. Hereditary hemochromatosis (HH) disrupts this balance, causing excessive dietary iron absorption and systemic iron overload. This thesis investigates the molecular mechanisms linking transferrin saturation sensing to BMP signaling in the liver, focusing on the roles of HFE, TFR2, and HJV. We demonstrate that these proteins form a complex required for BMP pathway activation and identify the cytoplasmic domain of TFR2 as critical for signaling. Additionally, we provide evidence for TFR2’s role in stress erythropoiesis, suggesting multifunctional roles in iron regulation and red blood cell production. These findings advance understanding of iron homeostasis and HH pathogenesis.
000002771 540__ $$fCC BY
000002771 542__ $$fIn copyright - single owner
000002771 650__ $$aHemochromatosis$$020035
000002771 650__ $$aMembrane Proteins$$022009
000002771 650__ $$aErythropoiesis$$018619
000002771 650__ $$aIron, Dietary$$031485
000002771 650__ $$aIron Overload$$031414
000002771 650__ $$aIron$$021036
000002771 650__ $$aReceptors, Transferrin$$025224
000002771 691__ $$aSchool of Medicine$$041369
000002771 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000002771 7001_ $$aWorthen, Christal$$uOregon Health and Science University$$041354
000002771 7201_ $$aEnns, Caroline$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000002771 8564_ $$9ffcfce9a-aedf-4b3c-9f4d-4dba76646eac$$s2500687$$uhttps://digitalcollections.ohsu.edu/record/2771/files/3537_etd.pdf$$ePublic$$20303b8e2fa0ac8d17104720c60b7c845$$31
000002771 905__ $$a/rest/prod/q2/37/hs/18/q237hs18x
000002771 909CO $$ooai:digitalcollections.ohsu.edu:2771$$pstudent-work
000002771 980__ $$aTheses and Dissertations