000002776 001__ 2776 000002776 005__ 20251204080324.0 000002776 0247_ $$2DOI$$a10.6083/M4KS6Q8K 000002776 037__ $$aETD 000002776 245__ $$aMeta-analysis of the influence of patient characteristics on the effectiveness and harms of recombinant human bone morphogenetic protein-2 in lumbar spinal fusion 000002776 260__ $$bOregon Health and Science University 000002776 269__ $$a2014 000002776 336__ $$aThesis 000002776 502__ $$bM.S. 000002776 502__ $$gBiostatistics 000002776 520__ $$aUsing individual patient data from 10 industry-sponsored randomized, controlled trials of rhBMP-2, including 1,255 patients, linear and generalized linear mixed models were used to assess the effects of patient characteristics on estimates of effectiveness and harms of rhBMP-2. The purpose of this project is to determine how patient characteristics impact estimates of effectiveness and harms of rhBMP-2 versus iliac crest bone graft (ICBG) in lumbar spinal fusion. 000002776 540__ $$fCC BY 000002776 542__ $$fIn copyright - single owner 000002776 650__ $$aBone Morphogenetic Protein 2$$038282 000002776 650__ $$aIntervertebral Disc Degeneration$$038529 000002776 650__ $$aHumans$$020376 000002776 650__ $$aTreatment Outcome$$029508 000002776 650__ $$aSpinal Fusion$$026286 000002776 691__ $$aSchool of Medicine$$041369 000002776 692__ $$aDepartment of Public Health and Preventive Medicine$$041444 000002776 7001_ $$aLaurie, Amber$$uOregon Health and Science University$$041354 000002776 7201_ $$aFu, Rochelle$$uOregon Health and Science University$$041354$$7Personal$$eMentor 000002776 8564_ $$9f4625a60-a500-47f9-a3a2-190a0e3da861$$s971947$$uhttps://digitalcollections.ohsu.edu/record/2776/files/3544_etd.pdf$$ePublic$$297aa4618b7d11e106e6c6977dfc45dd4$$31 000002776 905__ $$a/rest/prod/bn/99/97/01/bn9997013 000002776 909CO $$ooai:digitalcollections.ohsu.edu:2776$$pstudent-work 000002776 980__ $$aTheses and Dissertations