@article{ETD,
      recid = {2816},
      author = {Birdsong, William},
      title = {Acid sensing ion channels: coincident detection of  ischemia by a channel-channel interaction},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2008},
      number = {ETD},
      abstract = {Acid‑sensing ion channels are sodium‑selective channels  gated by extracellular protons and are known to play a role  in sensing ischemic conditions. Ischemia occurs when a  tissue receives insufficient oxygen to meet its metabolic  demands, leading to metabolic imbalance, pain, and tissue  damage. A longstanding paradox has been how acid‑sensing  ion channels function effectively within the complex  ischemic environment. The work presented in this  dissertation addresses this question and describes the  discovery of a synergistic interaction between  extracellular acidity and adenosine triphosphate (ATP) in  modulating ion channel activity.},
      url = {http://digitalcollections.ohsu.edu/record/2816},
      doi = {https://doi.org/10.6083/M42J69KK},
}