TY  - GEN
AB  - Acid‑sensing ion channels are sodium‑selective channels gated by extracellular protons and are known to play a role in sensing ischemic conditions. Ischemia occurs when a tissue receives insufficient oxygen to meet its metabolic demands, leading to metabolic imbalance, pain, and tissue damage. A longstanding paradox has been how acid‑sensing ion channels function effectively within the complex ischemic environment. The work presented in this dissertation addresses this question and describes the discovery of a synergistic interaction between extracellular acidity and adenosine triphosphate (ATP) in modulating ion channel activity.
AD  - Oregon Health and Science University
AU  - Birdsong, William
DA  - 2008
DO  - 10.6083/M42J69KK
DO  - DOI
ID  - 2816
KW  - Ischemia
KW  - Sodium Channels
KW  - Acid Sensing Ion Channels
KW  - Receptors, Purinergic P2
KW  - ion sodium gating
L1  - https://digitalcollections.ohsu.edu/record/2816/files/3584_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2816/files/3584_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2816/files/3584_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2816/files/3584_etd.pdf
N2  - Acid‑sensing ion channels are sodium‑selective channels gated by extracellular protons and are known to play a role in sensing ischemic conditions. Ischemia occurs when a tissue receives insufficient oxygen to meet its metabolic demands, leading to metabolic imbalance, pain, and tissue damage. A longstanding paradox has been how acid‑sensing ion channels function effectively within the complex ischemic environment. The work presented in this dissertation addresses this question and describes the discovery of a synergistic interaction between extracellular acidity and adenosine triphosphate (ATP) in modulating ion channel activity.
PB  - Oregon Health and Science University
PY  - 2008
T1  - Acid sensing ion channels: coincident detection of ischemia by a channel-channel interaction
TI  - Acid sensing ion channels: coincident detection of ischemia by a channel-channel interaction
UR  - https://digitalcollections.ohsu.edu/record/2816/files/3584_etd.pdf
Y1  - 2008
ER  -