000002816 001__ 2816
000002816 005__ 20260410130553.0
000002816 0247_ $$2DOI$$a10.6083/M42J69KK
000002816 037__ $$aETD
000002816 245__ $$aAcid sensing ion channels: coincident detection of ischemia by a channel-channel interaction
000002816 260__ $$bOregon Health and Science University
000002816 269__ $$a2008
000002816 336__ $$aDissertation
000002816 502__ $$bPh.D.
000002816 502__ $$gNeuroscience
000002816 520__ $$aAcid‑sensing ion channels are sodium‑selective channels gated by extracellular protons and are known to play a role in sensing ischemic conditions. Ischemia occurs when a tissue receives insufficient oxygen to meet its metabolic demands, leading to metabolic imbalance, pain, and tissue damage. A longstanding paradox has been how acid‑sensing ion channels function effectively within the complex ischemic environment. The work presented in this dissertation addresses this question and describes the discovery of a synergistic interaction between extracellular acidity and adenosine triphosphate (ATP) in modulating ion channel activity.
000002816 540__ $$fCC BY
000002816 542__ $$fIn copyright - single owner
000002816 650__ $$aIschemia$$021046
000002816 650__ $$aSodium Channels$$028231
000002816 650__ $$aAcid Sensing Ion Channels$$040087
000002816 650__ $$aReceptors, Purinergic P2$$030459
000002816 6531_ $$aion sodium gating
000002816 691__ $$aSchool of Medicine$$041369
000002816 692__ $$aVollum Institute$$041509
000002816 7001_ $$aBirdsong, William$$uOregon Health and Science University$$041354
000002816 8564_ $$9a4197dec-09d7-4df1-ab56-5744b37227e7$$s12911101$$uhttps://digitalcollections.ohsu.edu/record/2816/files/3584_etd.pdf$$ePublic$$2519665e69a30c85c84668de0d5ed53c5$$31
000002816 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000002816 905__ $$a/rest/prod/b8/51/5n/60/b8515n60s
000002816 909CO $$ooai:digitalcollections.ohsu.edu:2816$$pstudent-work
000002816 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002816 980__ $$aTheses and Dissertations