000002834 001__ 2834
000002834 005__ 20260120144902.0
000002834 0247_ $$2DOI$$a10.6083/M4QN65HZ
000002834 037__ $$aETD
000002834 245__ $$aExosome trafficking in the acute myeloid leukemia microenvironment
000002834 260__ $$aOregon Health and Science University
000002834 269__ $$a2015
000002834 336__ $$aDissertation
000002834 502__ $$bPh.D.
000002834 520__ $$aIn these experiments, I begin to delineate the role of AML-derived  exosomes  in  the  regulation  of  the  marrow  microenvironment.    Through  electron   and  fluorescence  microscopy,  nanoparticle  tracking  analysis,  and  microRNA   microarray, I demonstrate that AML blasts secrete exosomes containing  concentrated  microRNA,  the  makeup  of  which  clearly  distinguishes  cells  from   exosomes and nonmalignant hematopoietic cells from AML blasts.  These  exosomes are taken up by both HSPC and marrow stroma, transferring sufficient  microRNA to effect as much as a 10-fold increase in cellular concentration.
000002834 540__ $$fCC BY
000002834 542__ $$fIn copyright - single owner
000002834 650__ $$aStem Cell Niche$$038188
000002834 650__ $$aExosomes$$038258
000002834 650__ $$aTumor Microenvironment$$039473
000002834 650__ $$aLeukemia, Myeloid, Acute$$028432
000002834 691__ $$aSchool of Medicine$$041369
000002834 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000002834 7001_ $$aHornick, Noah$$uOregon Health and Science University$$041354
000002834 7201_ $$aKurre, Peter$$uOregon Health and Science University$$041354$$7Personal$$eMentor$$eAdvisor
000002834 8564_ $$997477b52-b92f-4f08-bfa8-a139abcdfa60$$s3589970$$uhttps://digitalcollections.ohsu.edu/record/2834/files/3602_etd.pdf$$ePublic$$2561ccefcb9443720fd34ea65c95df724$$31
000002834 905__ $$a/rest/prod/00/00/00/16/00000016w
000002834 909CO $$ooai:digitalcollections.ohsu.edu:2834$$pstudent-work
000002834 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000002834 980__ $$aTheses and Dissertations