000002836 001__ 2836 000002836 005__ 20251031142010.0 000002836 0247_ $$2DOI$$a10.6083/M4G44P1S 000002836 037__ $$aETD 000002836 245__ $$aStrad pseudokinases are critical in embroyonic brain development and in regulating LKB1 stability 000002836 260__ $$bOregon Health and Science University 000002836 269__ $$a2015 000002836 336__ $$aDissertation 000002836 502__ $$bPh.D. 000002836 502__ $$gNeuroscience 000002836 520__ $$aThe STe20-Related ADapter (STRAD) pseudokinases are highly evolutionarily conserved regulators of the protein kinase LKB1, but the roles of the vertebrate paralogs STRADα and STRADβ in the developing nervous system are not fully defined, nor is it known whether they serve distinct functions given their high degree of homology. Our phylogenetic analysis indicates that STRADα is the primal STRAD gene with STRADβ appearing following a gene duplication event solely in vertebrate species. The discovery and description of a hereditary developmental epilepsy syndrome known as Polyhydramnios, Megalencephaly, and Symptomatic Epilepsy (PMSE) Syndrome caused by homozygous deletion of part of the STRADα gene indicates that this family of proteins plays a key role in development. I conducted biochemical and genetic analyses to better understand the contribution of the STRAD pseudokinases to vertebrate brain patterning. 000002836 540__ $$fCC BY 000002836 542__ $$fIn copyright - single owner 000002836 650__ $$aBrain$$015788 000002836 650__ $$aGenes$$019447 000002836 650__ $$aCell Polarity$$029391 000002836 6531_ $$aaxons etiology 000002836 6531_ $$anervous system growth and development 000002836 691__ $$aSchool of Medicine$$041369 000002836 692__ $$aVollum Institute$$041509 000002836 7001_ $$aVeleva-Rotse, Biliana$$uOregon Health and Science University$$041354 000002836 8564_ $$9fa577c72-a411-4155-bdbe-a84e9537e73d$$s44110122$$uhttps://digitalcollections.ohsu.edu/record/2836/files/3604_etd.pdf$$ePublic$$2ecdffdb0031945f78d9f4e3e9a720336$$31 000002836 905__ $$a/rest/prod/fx/71/9m/61/fx719m615 000002836 909CO $$ooai:digitalcollections.ohsu.edu:2836$$pstudent-work 000002836 980__ $$aTheses and Dissertations 000002836 980__ $$aDual Author Affiliations Cleanup