TY  - GEN
AB  - Hepatocellular carcinoma (HCC) is a serious global public health issue. With 782,000  new cases diagnosed in 2012, HCC is the second leading cause of death related to  cancer worldwide. The majority of HCC cases occur in developing countries in  Southeast Asia, Sub-Saharan Africa and China. Hepatitis B virus (HBV) infection and  aflatoxin exposure are the two main factors contributing to HCC in these high incidence  regions. While HBV vaccination provides an effective way to lower the risk of HCC,  there are an estimated 5 billion people at risk of chronic exposure to aflatoxins through  contaminated food. To develop effective treatment, early diagnosis, and intervention  strategies, a better understanding of the mechanisms by which aflatoxins induce HCC is  paramount.
AD  - Oregon Health and Science University
AU  - Lin, Ying-Chih
DA  - 2015
DO  - 10.6083/M4BC3X8M
DO  - DOI
ED  - Lloyd, Stephen
ED  - Advisor
ID  - 2837
KW  - Genomic Instability
KW  - DNA Damage
KW  - DNA Repair
KW  - Mutagenesis
KW  - Aflatoxins
KW  - Carcinoma, Hepatocellular
L1  - https://digitalcollections.ohsu.edu/record/2837/files/3607_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2837/files/3607_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2837/files/3607_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2837/files/3607_etd.pdf
N2  - Hepatocellular carcinoma (HCC) is a serious global public health issue. With 782,000  new cases diagnosed in 2012, HCC is the second leading cause of death related to  cancer worldwide. The majority of HCC cases occur in developing countries in  Southeast Asia, Sub-Saharan Africa and China. Hepatitis B virus (HBV) infection and  aflatoxin exposure are the two main factors contributing to HCC in these high incidence  regions. While HBV vaccination provides an effective way to lower the risk of HCC,  there are an estimated 5 billion people at risk of chronic exposure to aflatoxins through  contaminated food. To develop effective treatment, early diagnosis, and intervention  strategies, a better understanding of the mechanisms by which aflatoxins induce HCC is  paramount.
PB  - Oregon Health and Science University
PY  - 2015
T1  - Mechanism of aflatoxin-induced mutagenesis
TI  - Mechanism of aflatoxin-induced mutagenesis
UR  - https://digitalcollections.ohsu.edu/record/2837/files/3607_etd.pdf
Y1  - 2015
ER  -