000002844 001__ 2844 000002844 005__ 20251113113803.0 000002844 0247_ $$2DOI$$a10.6083/M4NP235V 000002844 037__ $$aETD 000002844 245__ $$aDengue epidemic in Puerto Rico 2012-2013: integration of passive and sentinel surveillance to characterize and differentiate dengue in the peri-vaccination era 000002844 260__ $$bOregon Health and Science University 000002844 269__ $$a2015 000002844 336__ $$aThesis 000002844 502__ $$bM.P.H. 000002844 520__ $$aDengue represents an increasingly important global health challenge, as recent estimates suggest that nearly 2.5 billion people worldwide are at risk for infection1 and 390 million infections occurred in 2010.2 The four dengue virus-types (DENV-1–4) that cause dengue are single-stranded, positive-sense RNA viruses of the family Flaviviridae. Aedes aegypti and Ae. albopictus mosquitoes are endemic throughout the tropics and subtropics and serve as the primary vector for DENV transmission. DENV infection can result in a range of outcomes, from asymptomatic infection, to self-limited acute febrile illness (AFI), to potentially fatal severe dengue. 000002844 540__ $$fCC BY 000002844 542__ $$fIn copyright - single owner 000002844 650__ $$aPublic Health$$024885 000002844 650__ $$aEpidemiology$$018518 000002844 650__ $$aDengue$$017470 000002844 651__ $$aPuerto Rico$$041111 000002844 691__ $$aSchool of Medicine$$041369 000002844 692__ $$aDepartment of Public Health and Preventive Medicine$$041444 000002844 7001_ $$aNoyd, David$$uOregon Health and Science University$$041354 000002844 7201_ $$aWinthrop, Kevin$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor 000002844 8564_ $$98fc673b2-9bff-414a-9465-39de96c21f69$$s1114253$$uhttps://digitalcollections.ohsu.edu/record/2844/files/3612_etd.pdf$$ePublic$$268737c2056a0cee7a1a510a7fe3dcba4$$31 000002844 905__ $$a/rest/prod/2b/88/qc/43/2b88qc43c 000002844 909CO $$ooai:digitalcollections.ohsu.edu:2844$$pstudent-work 000002844 980__ $$aTheses and Dissertations