000002858 001__ 2858 000002858 005__ 20250424232759.0 000002858 0247_ $$2DOI$$a10.6083/M42R3QD7 000002858 037__ $$aETD 000002858 245__ $$aEpistasis, polygenic effects, and the missing heritability problem: a review of machine learning as applied to genetic association studies 000002858 260__ $$bOregon Health and Science University 000002858 269__ $$a2015 000002858 336__ $$aCapstone 000002858 502__ $$bM.B.I. 000002858 502__ $$gBiomedical Informatics 000002858 520__ $$aIn recent years, there has been a significant academic drive to determine the cause of the missing heritability problem which is commonly associated with the genetics of complex traits such as complex diseases. In this paper, I present an in-depth literature review by introducing the nature of this problem and discussing the current state of genetic association studies which commonly involves multi-locus models as predictors (as opposed to the conventional single-locus association studies) that became prominent with the advent of genome-wide sequencing technology. 000002858 540__ $$fCC BY 000002858 542__ $$fIn copyright - single owner 000002858 650__ $$aArtificial Intelligence$$015109 000002858 650__ $$aGenome-Wide Association Study$$038168 000002858 650__ $$aGenetic Association Studies$$038681 000002858 650__ $$aEpistasis, Genetic$$018546 000002858 650__ $$aChromosome Mapping$$016681 000002858 650__ $$aMultifactorial Inheritance$$032399 000002858 650__ $$aMachine Learning$$011449 000002858 691__ $$aSchool of Medicine$$041369 000002858 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422 000002858 7001_ $$aJenson, Peter$$uOregon Health and Science University$$041354 000002858 7201_ $$aMooney, Michael$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor 000002858 8564_ $$92d2351ba-cdf1-4555-81bb-01263a96d5b9$$s2266645$$uhttps://digitalcollections.ohsu.edu/record/2858/files/3626_etd.pdf$$ePublic$$2920ac280c6614204db313b070c670a1b$$31 000002858 905__ $$a/rest/prod/89/10/jt/75/8910jt75s 000002858 909CO $$ooai:digitalcollections.ohsu.edu:2858$$pstudent-work 000002858 980__ $$aBiomedical Informatics