TY  - GEN
AB  - During  central  nervous  system  (CNS)  development,  neural  progenitor  cells  undergo  dramatic changes in gene expression to differentiate into diverse types of neurons. One of  the  fundamental  challenges  in  neurobiology  is  to  understand  the  molecular  mechanisms  that  drive  this  drastic  and  thorough  transformation  of  the  gene  expression  profile.  Previous  research  suggests  that  transcription  factors  are  the  primary  regulators  of  gene  expression changes during neurogenesis. However, recent studies have shown that  microRNAs  (miRNAs)  are  also  important  components  of  the  gene  regulatory  networks  that direct neuronal cell fate. The extent to which miRNAs collaborate with transcription  factors in the gene network that determines neuronal identity remains unclear.
AD  - Oregon Health and Science University
AU  - Thiebes, Karen
DA  - 2015
DO  - 10.6083/M4697299
DO  - DOI
ED  - Lee, Soo-Kyung
ED  - Advisor
ID  - 2878
KW  - Spinal Cord
KW  - MicroRNAs
KW  - Motor Neurons
KW  - mirn218 microrna
L1  - https://digitalcollections.ohsu.edu/record/2878/files/3647_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2878/files/3647_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2878/files/3647_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2878/files/3647_etd.pdf
N2  - During  central  nervous  system  (CNS)  development,  neural  progenitor  cells  undergo  dramatic changes in gene expression to differentiate into diverse types of neurons. One of  the  fundamental  challenges  in  neurobiology  is  to  understand  the  molecular  mechanisms  that  drive  this  drastic  and  thorough  transformation  of  the  gene  expression  profile.  Previous  research  suggests  that  transcription  factors  are  the  primary  regulators  of  gene  expression changes during neurogenesis. However, recent studies have shown that  microRNAs  (miRNAs)  are  also  important  components  of  the  gene  regulatory  networks  that direct neuronal cell fate. The extent to which miRNAs collaborate with transcription  factors in the gene network that determines neuronal identity remains unclear.
PB  - Oregon Health and Science University
PY  - 2015
T1  - MicroRNA function in developing spinal cord motor neurons
TI  - MicroRNA function in developing spinal cord motor neurons
UR  - https://digitalcollections.ohsu.edu/record/2878/files/3647_etd.pdf
Y1  - 2015
ER  -