000002878 001__ 2878 000002878 005__ 20251104075900.0 000002878 0247_ $$2DOI$$a10.6083/M4697299 000002878 037__ $$aETD 000002878 245__ $$aMicroRNA function in developing spinal cord motor neurons 000002878 260__ $$bOregon Health and Science University 000002878 269__ $$a2015 000002878 336__ $$aDissertation 000002878 502__ $$bPh.D. 000002878 502__ $$gNeuroscience 000002878 520__ $$aDuring central nervous system (CNS) development, neural progenitor cells undergo dramatic changes in gene expression to differentiate into diverse types of neurons. One of the fundamental challenges in neurobiology is to understand the molecular mechanisms that drive this drastic and thorough transformation of the gene expression profile. Previous research suggests that transcription factors are the primary regulators of gene expression changes during neurogenesis. However, recent studies have shown that microRNAs (miRNAs) are also important components of the gene regulatory networks that direct neuronal cell fate. The extent to which miRNAs collaborate with transcription factors in the gene network that determines neuronal identity remains unclear. 000002878 540__ $$fCC BY 000002878 542__ $$fIn copyright - single owner 000002878 650__ $$aSpinal Cord$$026279 000002878 650__ $$aMicroRNAs$$034671 000002878 650__ $$aMotor Neurons$$022454 000002878 6531_ $$amirn218 microrna 000002878 691__ $$aSchool of Medicine$$041369 000002878 692__ $$aVollum Institute$$041509 000002878 7001_ $$aThiebes, Karen$$uOregon Health and Science University$$041354 000002878 7201_ $$aLee, Soo-Kyung$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor 000002878 8564_ $$9b76affde-2bf9-4965-a140-64a82acd978b$$s43899913$$uhttps://digitalcollections.ohsu.edu/record/2878/files/3647_etd.pdf$$ePublic$$26ac09247727771649396853248253316$$31 000002878 905__ $$a/rest/prod/s4/65/5g/77/s4655g77r 000002878 909CO $$ooai:digitalcollections.ohsu.edu:2878$$pstudent-work 000002878 980__ $$aTheses and Dissertations