TY  - GEN
AB  - The    goal    of    this    research    is    to    characterize    the    contribution    of    histidine    and     methionine    to    function    in    copper    proteins.    The    emergence    of    His    and    Met    residues     in    copper    proteins    is    not    new,    but    the    flexible    dynamic    provided    is    novel    and    has     been    shown    to    alter    function.    We    have    characterized    the    pH-­‐dependent     coordination    chemistry    involving    His-­‐Met    residues    in    cuproproteins    peptidylglycine     hydroxylating    monooxygenase    (PHM)    and    the    HM    Loop    of    ATP7A,    which    is    involved     in    copper    translocation.
AD  - Oregon Health and Science University
AU  - Kline, Chelsey
DA  - 2015
DO  - 10.6083/M4XW4HJ2
DO  - DOI
ED  - Blackburn, Ninian
ED  - Mayfield, Mary
ED  - Advisor
ED  - Mentor
ID  - 2880
KW  - Copper
KW  - Biological Transport
KW  - X-Ray Absorption Spectroscopy
KW  - Biochemistry
L1  - https://digitalcollections.ohsu.edu/record/2880/files/3649_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2880/files/3649_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2880/files/3649_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2880/files/3649_etd.pdf
N2  - The    goal    of    this    research    is    to    characterize    the    contribution    of    histidine    and     methionine    to    function    in    copper    proteins.    The    emergence    of    His    and    Met    residues     in    copper    proteins    is    not    new,    but    the    flexible    dynamic    provided    is    novel    and    has     been    shown    to    alter    function.    We    have    characterized    the    pH-­‐dependent     coordination    chemistry    involving    His-­‐Met    residues    in    cuproproteins    peptidylglycine     hydroxylating    monooxygenase    (PHM)    and    the    HM    Loop    of    ATP7A,    which    is    involved     in    copper    translocation.
PB  - Oregon Health and Science University
PY  - 2015
T1  - Histidine-methionine contributions to function in copper proteins
TI  - Histidine-methionine contributions to function in copper proteins
UR  - https://digitalcollections.ohsu.edu/record/2880/files/3649_etd.pdf
Y1  - 2015
ER  -