000002887 001__ 2887
000002887 005__ 20251104072634.0
000002887 0247_ $$2DOI$$a10.6083/M4833QSG
000002887 037__ $$aETD
000002887 245__ $$aOpioid pathways in methamphetamine intake
000002887 260__ $$bOregon Health and Science University
000002887 269__ $$a2015
000002887 336__ $$aDissertation
000002887 502__ $$bPh.D.
000002887 520__ $$aMethamphetamine (MA) is a powerful psychostimulant and its excessive use is linked to neurotoxicity and neuropsychiatric disorders. However, not all initial users develop drug use disorders and it is possible that genetic differences render some individuals more susceptible to the addictive properties of MA compared to others. Genetic differences in avidity for MA have been studied using two replicate sets of selectively bred MA drinking (MADR) mouse lines that voluntarily consume either high (MAHDR) or low (MALDR) amounts of MA. Selective breeding  alters allele frequencies; thus, alleles that increase MA drinking (MADR) have aggregated in the MAHDR line mice, whereas alleles that reduce MA intake have aggregated in the MALDR line mice. A gene mapping study identified a major effect genetic locus on mouse chromosome  (Chr) 10 that accounts for more than 50% of the genetic variance associated with this  differential MA intake. Oprm1 lies within the mapped region and previous gene expression  analysis added support for Oprm1 as a candidate gene on Chr 10 that influences MA drinking.  Based on published basic and human clinical data and preliminary data obtained within our  laboratory, I hypothesized that Oprm1 genetic variation and mu-opioid receptor (MOP-r)- regulated systems are important in influencing MA intake.
000002887 540__ $$fCC BY
000002887 542__ $$fIn copyright - single owner
000002887 650__ $$aNucleus Accumbens$$023067
000002887 650__ $$aSubstance-Related Disorders$$032029
000002887 650__ $$aAmphetamine$$014624
000002887 650__ $$aDrinking Behavior$$018055
000002887 650__ $$aPrefrontal Cortex$$029938
000002887 650__ $$aReceptors, Opioid, mu$$029979
000002887 691__ $$aSchool of Medicine$$041369
000002887 692__ $$aDepartment of Behavioral Neuroscience$$041394
000002887 7001_ $$aEastwood, Emily$$uOregon Health and Science University$$041354
000002887 7201_ $$aPhillips, Tamara$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000002887 8564_ $$96d9c6304-ef51-40be-bf5f-f943f0f70012$$s2347633$$uhttps://digitalcollections.ohsu.edu/record/2887/files/3656_etd.pdf$$ePublic$$243980c63e283c878a17d247b87f99b1a$$31
000002887 905__ $$a/rest/prod/zp/38/wc/88/zp38wc88n
000002887 909CO $$ooai:digitalcollections.ohsu.edu:2887$$pstudent-work
000002887 980__ $$aTheses and Dissertations