000002895 001__ 2895
000002895 005__ 20251113092459.0
000002895 0247_ $$2DOI$$a10.6083/M4FQ9VBB
000002895 037__ $$aETD
000002895 245__ $$aDevelopment of nanoparticle platform for therapeutic siRNA and drug delivery to breast cancer
000002895 260__ $$bOregon Health and Science University
000002895 269__ $$a2015
000002895 336__ $$aDissertation
000002895 502__ $$bPh.D.
000002895 520__ $$aDespite the advent of novel targeted therapies and early diagnosis, breast cancer  remains  the  second  cause  of  cancer  death  in  women  in  the  US  since  1950.   More effective treatments are still needed to improve its prognosis. Her2-positive  (HER2+)  breast  cancer  represents  15-25%  of  invasive  breast  cancer. In  this  dissertation  project,  a  novel  nanoparticle  construct  has  been  engineered  for  efficient  delivery  of  siRNAs  to  tumors.
000002895 540__ $$fCC BY
000002895 542__ $$fIn copyright - single owner
000002895 650__ $$aMolecular Targeted Therapy$$039450
000002895 650__ $$aSilicates$$030131
000002895 650__ $$aBreast Neoplasms$$015809
000002895 650__ $$aDrug Delivery Systems$$029171
000002895 650__ $$aNanoparticles$$037592
000002895 650__ $$aRNA, Small Interfering$$034596
000002895 691__ $$aSchool of Medicine$$041369
000002895 692__ $$aDepartment of Biomedical Engineering$$041397
000002895 7001_ $$aNgamcherdtrakul, Worapol$$uOregon Health and Science University$$041354
000002895 7201_ $$aYantasee, Wassana$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000002895 8564_ $$9749ca682-2de3-4e0b-b28c-848abf42e66d$$s5538955$$uhttps://digitalcollections.ohsu.edu/record/2895/files/3665_etd.pdf$$ePublic$$21be14ad774bc9d10c665b805ff1c18f2$$31
000002895 905__ $$a/rest/prod/1z/40/kt/06/1z40kt06x
000002895 909CO $$ooai:digitalcollections.ohsu.edu:2895$$pstudent-work
000002895 980__ $$aTheses and Dissertations