000002969 001__ 2969 000002969 005__ 20251114123041.0 000002969 0247_ $$2DOI$$a10.6083/M4PR7TX9 000002969 037__ $$aETD 000002969 245__ $$aA response-adaptive covariate-balanced randomization for multi-arm clinical trials 000002969 260__ $$bOregon Health and Science University 000002969 269__ $$a2015 000002969 336__ $$aThesis 000002969 502__ $$bM.S. 000002969 520__ $$aRandomization is a key characteristic of clinical trials which makes them the gold standard for determining treatment effectiveness. Response-adaptive randomization is desirable because it allows more patients to receive the best treatment; however, compared to traditional equal randomization, response-adaptive randomization is more likely to allow imbalance in prognostic baseline covariates. We propose a simple yet flexible two-stage randomization for multi-arm trials which marries response-adaptative and covariate- balancing designs. The operating characteristics of the proposed methods were assessed via simulation for a variety of scenarios in which values of treatment success probability and patient response delay time were varied. 000002969 540__ $$fCC BY 000002969 542__ $$fIn copyright - single owner 000002969 650__ $$aRandom Allocation$$025135 000002969 650__ $$aClinical Trials as Topic$$016787 000002969 691__ $$aSchool of Medicine$$041369 000002969 692__ $$aDepartment of Public Health and Preventive Medicine$$041444 000002969 7001_ $$aBallou, Cassandra$$uOregon Health and Science University$$041354 000002969 7201_ $$aChen, Yiyi$$uOregon Health and Science University$$041354$$7Personal$$eMentor 000002969 8564_ $$9fdb616c9-8a2b-4ec1-b60d-4d634a3fa2c1$$s1558228$$uhttps://digitalcollections.ohsu.edu/record/2969/files/3743_etd.pdf$$ePublic$$29042786d792d8944dd00ca0bd3ef477a$$31 000002969 905__ $$a/rest/prod/q5/24/jn/96/q524jn96b 000002969 909CO $$ooai:digitalcollections.ohsu.edu:2969$$pstudent-work 000002969 980__ $$aTheses and Dissertations 000002969 980__ $$aDual Author Affiliations Cleanup