000002970 001__ 2970
000002970 005__ 20251103131015.0
000002970 0247_ $$2DOI$$a10.6083/M4K07374
000002970 037__ $$aETD
000002970 245__ $$aSimian varicella virus and varicella-zoster virus immune evasion of NFkB activation
000002970 269__ $$a2015
000002970 336__ $$aDissertation
000002970 502__ $$bPh.D.
000002970 520__ $$aVaricella Zoster Virus (VZV) causes chickenpox upon primary infection and establishes  latency in ganglia. Reactivation from latency causes herpes zoster, which may be  complicated by post-herpetic neuralgia. Innate immunity mediated by interferon and pro- inflammatory cytokines represents the first line of immune defense upon infection and  reactivation. VZV is known to interfere with multiple innate immune signaling pathways  including the central transcription factor NFĸB. However the role of these inhibitory  mechanisms in vivo is unknown. Simian varicella virus (SVV)-infection of rhesus  macaques recapitulates key aspects of VZV pathogenesis and this model thus permits  examining the role of immune evasion mechanisms in vivo.
000002970 540__ $$fCC BY
000002970 542__ $$fIn copyright - single owner
000002970 650__ $$aUbiquitin$$033233
000002970 650__ $$aImmune Evasion$$038852
000002970 650__ $$aProtein Serine-Threonine Kinases$$029894
000002970 650__ $$aHerpesvirus 3, Human$$027725
000002970 691__ $$aSchool of Medicine$$041369
000002970 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000002970 7001_ $$aWhitmer, Travis$$uOregon Health and Science University$$041354
000002970 7201_ $$aFrüh, Klaus$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000002970 8564_ $$97e0a6d01-7119-4cd4-a854-9d45c9ded787$$s2570718$$uhttps://digitalcollections.ohsu.edu/record/2970/files/3744_etd.pdf$$ePublic$$2462fb45822822136149099d7f7ba4d0f$$31
000002970 905__ $$a/rest/prod/08/61/2n/72/08612n72t
000002970 909CO $$ooai:digitalcollections.ohsu.edu:2970$$pstudent-work
000002970 980__ $$aTheses and Dissertations