TY  - GEN
AB  - Multiple  sclerosis  (MS)  is  an  inflammatory  disease  of  the  central  nervous  system  (CNS)  and  a  leading  cause  of  non-traumatic  neurological  disability  in  young  and  middle  aged  adults.1  Diagnosis,  monitoring,  and  the  study  of  MS  all  rely  heavily  on  magnetic  resonance  imaging  (MRI)  thanks  to  its  ability  to  non-invasively observe brain tissue pathology in-vivo. A variety of advanced imaging techniques  have  been  proposed  to  evaluate  tissue  and  vascular  properties including water content, myelin content (to assess demyelination and remyelination), vascular permeability (BBB breakdown in the case of  neuroinflammatory  diseases),  and  vascular  density  in-vivo.  In  vivo  magnetic  resonance  imaging  biomarkers  of  disease  were  developed  in  two  separate  animal models of MS and subsequently extended to human studies.
AD  - Oregon Health and Science University
AU  - Tagge, Ian
DA  - 2016-01-01
DO  - 10.6083/M4W0951T
DO  - DOI
ED  - Rooney, William
ED  - Advisor
ED  - Mentor
ID  - 2983
KW  - Remyelination
KW  - Capillary Permeability
KW  - Biomarkers
KW  - Microvascular Density
KW  - Magnetic Resonance Imaging
KW  - Brain
KW  - Neuroinflammatory Diseases
KW  - Myelin Sheath
KW  - Central Nervous System
KW  - Multiple Sclerosis
L1  - https://digitalcollections.ohsu.edu/record/2983/files/3770_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2983/files/3770_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2983/files/3770_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2983/files/3770_etd.pdf
N2  - Multiple  sclerosis  (MS)  is  an  inflammatory  disease  of  the  central  nervous  system  (CNS)  and  a  leading  cause  of  non-traumatic  neurological  disability  in  young  and  middle  aged  adults.1  Diagnosis,  monitoring,  and  the  study  of  MS  all  rely  heavily  on  magnetic  resonance  imaging  (MRI)  thanks  to  its  ability  to  non-invasively observe brain tissue pathology in-vivo. A variety of advanced imaging techniques  have  been  proposed  to  evaluate  tissue  and  vascular  properties including water content, myelin content (to assess demyelination and remyelination), vascular permeability (BBB breakdown in the case of  neuroinflammatory  diseases),  and  vascular  density  in-vivo.  In  vivo  magnetic  resonance  imaging  biomarkers  of  disease  were  developed  in  two  separate  animal models of MS and subsequently extended to human studies.
PB  - Oregon Health and Science University
PY  - 2016-01-01
T1  - In-vivo magnetic resonance imaging biomarkers of neuroinflammatory demyelinating disease
TI  - In-vivo magnetic resonance imaging biomarkers of neuroinflammatory demyelinating disease
UR  - https://digitalcollections.ohsu.edu/record/2983/files/3770_etd.pdf
Y1  - 2016-01-01
ER  -