TY  - GEN
AB  - Kaposi  sarcoma  (KS)  is  an  angioproliferative  tumor  with  infectious etiology, driven by viral infection of endothelial cells (EC) by Kaposi sarcoma herpesvirus (KSHV/HHV8). KS is the most common AIDS-associated malignancy,  resulting  in  significant morbidity  and  mortality  in  the  absence  of immune-reconstitution. While KS incidence has decreased substantially in the post-HAART  era,  there  is  an  ongoing  need  for  affordable  and  effective therapies  that  specifically  target  KS/KSHV,  particularly  in  resource-limited areas where KS is endemic and KSHV/HIV co-infection rates are high. In my dissertation, I aim to provide an in-depth review of the research to  date  on  KSHV  with  a  focus  on  how  host  genes,  such  as  HO-1,  can modulate  KSHV  infection  and  tumorigenesis.
AD  - Oregon Health and Science University
AU  - Botto, Sara
DA  - 2016-06-01
DO  - 10.6083/M45B01JD
DO  - DOI
ED  - Moses, Ashlee
ED  - Advisor
ID  - 2990
KW  - Carcinogenesis
KW  - Coinfection
KW  - HIV Infections
KW  - Antiretroviral Therapy, Highly Active
KW  - Acquired Immunodeficiency Syndrome
KW  - Sarcoma, Kaposi
KW  - Neoplasms
KW  - Virus Diseases
KW  - Herpesvirus 8, Human
L1  - https://digitalcollections.ohsu.edu/record/2990/files/3791_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/2990/files/3791_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/2990/files/3791_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/2990/files/3791_etd.pdf
N2  - Kaposi  sarcoma  (KS)  is  an  angioproliferative  tumor  with  infectious etiology, driven by viral infection of endothelial cells (EC) by Kaposi sarcoma herpesvirus (KSHV/HHV8). KS is the most common AIDS-associated malignancy,  resulting  in  significant morbidity  and  mortality  in  the  absence  of immune-reconstitution. While KS incidence has decreased substantially in the post-HAART  era,  there  is  an  ongoing  need  for  affordable  and  effective therapies  that  specifically  target  KS/KSHV,  particularly  in  resource-limited areas where KS is endemic and KSHV/HIV co-infection rates are high. In my dissertation, I aim to provide an in-depth review of the research to  date  on  KSHV  with  a  focus  on  how  host  genes,  such  as  HO-1,  can modulate  KSHV  infection  and  tumorigenesis.
PY  - 2016-06-01
T1  - Kaposi sarcoma associated herpesvirus and heme oxygenase-1: the bidirectional relationship between virus and host
TI  - Kaposi sarcoma associated herpesvirus and heme oxygenase-1: the bidirectional relationship between virus and host
UR  - https://digitalcollections.ohsu.edu/record/2990/files/3791_etd.pdf
Y1  - 2016-06-01
ER  -