TY - GEN AB - Thyroid hormones control a wide range of physiological processes in all known vertebrates. These actions are mediated by two different receptor subtypes that have heterogeneous distribution in tissues. While the endogenous hormone does not distinguish between the two subtypes, synthetic ligands have been made that will preferentially activate one subtype over the other in vitro. AD - Oregon Health and Science University AU - Devereaux, Jordan DA - 2016-06-01 DO - 10.6083/M41J98T4 DO - DOI ED - Scanlan, Thomas ED - Advisor ID - 2991 KW - Blood-Brain Barrier KW - Pharmacokinetics KW - Chemistry, Pharmaceutical KW - Thyroid Hormones L1 - https://digitalcollections.ohsu.edu/record/2991/files/3792_etd.pdf L2 - https://digitalcollections.ohsu.edu/record/2991/files/3792_etd.pdf L4 - https://digitalcollections.ohsu.edu/record/2991/files/3792_etd.pdf LK - https://digitalcollections.ohsu.edu/record/2991/files/3792_etd.pdf N2 - Thyroid hormones control a wide range of physiological processes in all known vertebrates. These actions are mediated by two different receptor subtypes that have heterogeneous distribution in tissues. While the endogenous hormone does not distinguish between the two subtypes, synthetic ligands have been made that will preferentially activate one subtype over the other in vitro. PY - 2016-06-01 T1 - New approaches for enhancing the selectivity and activity of thyroid hormone analogs TI - New approaches for enhancing the selectivity and activity of thyroid hormone analogs UR - https://digitalcollections.ohsu.edu/record/2991/files/3792_etd.pdf Y1 - 2016-06-01 ER -