TY  - GEN
AB  - Fast chemical synapses mediate rapid communications between neurons. Interestingly, the strength of most synapses is not constant but dynamic, depending on the history of presynaptic activity. In many cases, repetitive activation of presynaptic neurons  leads to a rapid decrease in synaptic strength, a phenomenon termed short-term depression. In this study, two synapses that exhibit profound short-term depression were investigated: a glycinergic inhibitory synapse in the auditory brainstem and a glutamatergic excitatory synapse in the cerebellum. The mechanisms underlying short-term depression at these two synapses are strikingly different, and consequently have distinct impacts at cellular or microcircuit level.
AD  - Oregon Health & Science University, Swedish Neuroscience Institute
AU  - Lu, Hsin-Wei
DA  - 2016-06-01
DO  - 10.6083/M4FN158F
DO  - DOI
ED  - Trussell, Laurence
ED  - Advisor
ID  - 3009
KW  - Cerebellum
KW  - Neurons
KW  - Synapses
L1  - https://digitalcollections.ohsu.edu/record/3009/files/3812_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/3009/files/3812_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/3009/files/3812_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/3009/files/3812_etd.pdf
N2  - Fast chemical synapses mediate rapid communications between neurons. Interestingly, the strength of most synapses is not constant but dynamic, depending on the history of presynaptic activity. In many cases, repetitive activation of presynaptic neurons  leads to a rapid decrease in synaptic strength, a phenomenon termed short-term depression. In this study, two synapses that exhibit profound short-term depression were investigated: a glycinergic inhibitory synapse in the auditory brainstem and a glutamatergic excitatory synapse in the cerebellum. The mechanisms underlying short-term depression at these two synapses are strikingly different, and consequently have distinct impacts at cellular or microcircuit level.
PY  - 2016-06-01
T1  - Pre- and post-synaptic regulation of two interneuron microcircuits in cerebellum-like structures
TI  - Pre- and post-synaptic regulation of two interneuron microcircuits in cerebellum-like structures
UR  - https://digitalcollections.ohsu.edu/record/3009/files/3812_etd.pdf
Y1  - 2016-06-01
ER  -