TY  - GEN
AB  - Tuberculosis (TB) is a pulmonary disease caused by Mycobacterium tuberculosis (Mtb).  Approximately one-third of the global population is infected with latent TB, an asymptomatic form of the disease that is phenotypically drug-tolerant.  Dormant Mtb reactivates when the immune system weakens, contributing to the nearly 10 million new cases of active TB that occur each year.   To better diagnose, treat, and ultimately eradicate TB, there is an urgent need to understand the enzymes associated with dormancy and reactivation. In my dissertation research, I used chemical tools to identify Mtb enzymatic activity associated with dormant, reactivating, and active Mtb.  My research focused on esterases, including the lipase subclass, which influence Mtb pathogenicity and reactivation from dormancy.
AD  - Oregon Health and Science University
AU  - Tallman, Katie
DA  - 2016-07-01
DO  - 10.6083/M42B8X4W
DO  - DOI
ED  - Beatty, Kimberly
ED  - Scanlan, Thomas
ED  - Ullman, Buddy
ED  - Cohen, Michael
ED  - Gibbs, Summer
ED  - Tafesse, Fikadu
ED  - Advisor
ED  - Committee chair
ED  - Committee member
ED  - Committee member
ED  - Committee member
ED  - Committee member
ID  - 3012
KW  - Virulence
KW  - Lipase
KW  - Esterases
KW  - Immune System
KW  - Latent Tuberculosis
KW  - Mycobacterium tuberculosis
KW  - Lung Diseases
KW  - Tuberculosis
L1  - https://digitalcollections.ohsu.edu/record/3012/files/3815_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/3012/files/3815_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/3012/files/3815_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/3012/files/3815_etd.pdf
N2  - Tuberculosis (TB) is a pulmonary disease caused by Mycobacterium tuberculosis (Mtb).  Approximately one-third of the global population is infected with latent TB, an asymptomatic form of the disease that is phenotypically drug-tolerant.  Dormant Mtb reactivates when the immune system weakens, contributing to the nearly 10 million new cases of active TB that occur each year.   To better diagnose, treat, and ultimately eradicate TB, there is an urgent need to understand the enzymes associated with dormancy and reactivation. In my dissertation research, I used chemical tools to identify Mtb enzymatic activity associated with dormant, reactivating, and active Mtb.  My research focused on esterases, including the lipase subclass, which influence Mtb pathogenicity and reactivation from dormancy.
PY  - 2016-07-01
T1  - The development and use of chemical tools to identify active mycobacterial esterases
TI  - The development and use of chemical tools to identify active mycobacterial esterases
UR  - https://digitalcollections.ohsu.edu/record/3012/files/3815_etd.pdf
Y1  - 2016-07-01
ER  -