TY  - GEN
AB  - Metastatic  spread  of  disease  accounts  for  the  overwhelming  majority  of   cancer-­related  deaths,  as  current  therapies  are  largely  ineffective  in  treating  this   phase  of  cancer.  This  highlights  our  lack  of  understanding  of  disease  progression   surrounding  metastatic  spread  of  disease. This  dissertation  provides  experimental  evidence  that  cell  fusion  is  a  mechanism   for  acquisition  of  metastatic  phenotypes,  and  also  presents  the  identification  of  a   novel  prognostic  circulating  biomarker  that  may  guide  treatment  regimens  in   patients.
AD  - Oregon Health and Science University
AU  - Gast, Charles
DA  - 2016
DO  - 10.6083/M4GB234D
DO  - DOI
ED  - Wong, Melissa
ED  - Coussens, Lisa
ED  - Advisor
ED  - Mentor
ED  - Advisor
ED  - Mentor
ID  - 3027
KW  - Macrophages
KW  - Cell Fusion
KW  - Breast Neoplasms
KW  - Disease Progression
KW  - Neoplasms, Second Primary
L1  - https://digitalcollections.ohsu.edu/record/3027/files/3840_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/3027/files/3840_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/3027/files/3840_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/3027/files/3840_etd.pdf
N2  - Metastatic  spread  of  disease  accounts  for  the  overwhelming  majority  of   cancer-­related  deaths,  as  current  therapies  are  largely  ineffective  in  treating  this   phase  of  cancer.  This  highlights  our  lack  of  understanding  of  disease  progression   surrounding  metastatic  spread  of  disease. This  dissertation  provides  experimental  evidence  that  cell  fusion  is  a  mechanism   for  acquisition  of  metastatic  phenotypes,  and  also  presents  the  identification  of  a   novel  prognostic  circulating  biomarker  that  may  guide  treatment  regimens  in   patients.
PB  - Oregon Health and Science University
PY  - 2016
T1  - Cell fusion potentiates tumor heterogeneity through acquisition of macrophage behavior
TI  - Cell fusion potentiates tumor heterogeneity through acquisition of macrophage behavior
UR  - https://digitalcollections.ohsu.edu/record/3027/files/3840_etd.pdf
Y1  - 2016
ER  -