000003027 001__ 3027
000003027 005__ 20251028144854.0
000003027 0247_ $$2DOI$$a10.6083/M4GB234D
000003027 037__ $$aETD
000003027 245__ $$aCell fusion potentiates tumor heterogeneity through acquisition of macrophage behavior
000003027 260__ $$bOregon Health and Science University
000003027 269__ $$a2016
000003027 336__ $$aDissertation
000003027 502__ $$bPh.D.
000003027 520__ $$aMetastatic  spread  of  disease  accounts  for  the  overwhelming  majority  of   cancer-­related  deaths,  as  current  therapies  are  largely  ineffective  in  treating  this   phase  of  cancer.  This  highlights  our  lack  of  understanding  of  disease  progression   surrounding  metastatic  spread  of  disease. This  dissertation  provides  experimental  evidence  that  cell  fusion  is  a  mechanism   for  acquisition  of  metastatic  phenotypes,  and  also  presents  the  identification  of  a   novel  prognostic  circulating  biomarker  that  may  guide  treatment  regimens  in   patients.
000003027 540__ $$fCC BY
000003027 542__ $$fIn copyright - single owner
000003027 650__ $$aMacrophages$$021733
000003027 650__ $$aCell Fusion$$016283
000003027 650__ $$aBreast Neoplasms$$015809
000003027 650__ $$aDisease Progression$$030807
000003027 650__ $$aNeoplasms, Second Primary$$029258
000003027 691__ $$aSchool of Medicine$$041369
000003027 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000003027 7001_ $$aGast, Charles$$uOregon Health and Science University$$041354$$10000-0002-6682-3152
000003027 7201_ $$aWong, Melissa$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000003027 7201_ $$aCoussens, Lisa$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000003027 8564_ $$9ec4fe7e9-e5e6-4e67-b62b-5bfac705a1b3$$s20274034$$uhttps://digitalcollections.ohsu.edu/record/3027/files/3840_etd.pdf$$ePublic$$2ae2bbeb3a91169eb3dc724ce42501f80$$31
000003027 905__ $$a/rest/prod/dj/52/w5/06/dj52w506g
000003027 909CO $$ooai:digitalcollections.ohsu.edu:3027$$pstudent-work
000003027 980__ $$aTheses and Dissertations