@article{ETD,
      recid = {3029},
      author = {Morry, Jingga},
      title = {Exploiting the antioxidant potential and siRNA delivery  function of mesoporous silica nanoparticles for the  treatment of skin fibrosis and breast cancer metastasis},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2016},
      number = {ETD},
      abstract = {The increased production of reactive oxygen species (ROS)  is a hallmark of fibrosis and  cancer. In fibrosis, the  release of ROS along  with secretion of pro-fibrotic  cytokines by  the  immune  cells  during  the  inflammatory   phase  has  been  known  to  promote  the  activation  of   fibroblasts  and  induce  collagen  deposition.  In   cancer,  ROS  also  plays  a  crucial  role  in  various   signaling  cascades  involved  in  cellular  survival,   proliferation,  resistance to apoptosis, angiogenesis, as  well as metastasis. However, the results from  clinical   studies  involving  antioxidant  therapies  in  patients   have  been  disappointing,  mostly due to the low  bioavailability of the conventional antioxidant therapies.},
      url = {http://digitalcollections.ohsu.edu/record/3029},
      doi = {https://doi.org/10.6083/M4PV6JGT},
}