TY - GEN AB - Network-based approaches are widely used for analyzing large-scale genomic data and searching for disease driver genes. Diffusion-based approaches are one of the most popular approaches for detecting disease candidate genes by combining biological information with topological network information. A particular diffusion-based algorithm used in The Cancer Genome Atlas data analysis called HotNet2 has been able to detect significant subnetworks of genes related to various cancer types. The purpose of this capstone project is to port HotNet2 from Python to Java. This will allow future integration into Java-based standalone projects that can provide users a more interactive user interface for the whole HotNet2 workflow. AD - Oregon Health and Science University AU - Yan, Melissa DA - 2016-12-01 DO - 10.6083/M4CC0ZRG DO - DOI ED - Wu, Guanming ED - Advisor ID - 3035 KW - Neoplasms KW - Genomics KW - Genome L1 - https://digitalcollections.ohsu.edu/record/3035/files/3860_etd.pdf L2 - https://digitalcollections.ohsu.edu/record/3035/files/3860_etd.pdf L4 - https://digitalcollections.ohsu.edu/record/3035/files/3860_etd.pdf LK - https://digitalcollections.ohsu.edu/record/3035/files/3860_etd.pdf N2 - Network-based approaches are widely used for analyzing large-scale genomic data and searching for disease driver genes. Diffusion-based approaches are one of the most popular approaches for detecting disease candidate genes by combining biological information with topological network information. A particular diffusion-based algorithm used in The Cancer Genome Atlas data analysis called HotNet2 has been able to detect significant subnetworks of genes related to various cancer types. The purpose of this capstone project is to port HotNet2 from Python to Java. This will allow future integration into Java-based standalone projects that can provide users a more interactive user interface for the whole HotNet2 workflow. PB - Oregon Health and Science University PY - 2016-12-01 T1 - Implementation of the HotNet2 network diffusion-based analysis method in Java TI - Implementation of the HotNet2 network diffusion-based analysis method in Java UR - https://digitalcollections.ohsu.edu/record/3035/files/3860_etd.pdf Y1 - 2016-12-01 ER -