000003038 001__ 3038
000003038 005__ 20251027094353.0
000003038 0247_ $$2DOI$$a10.6083/M46Q1WBJ
000003038 037__ $$aETD
000003038 245__ $$aThe role of protein phosphatase 4 in glial immune responses to neuronal injury
000003038 260__ $$bOregon Health and Science University
000003038 269__ $$a2016
000003038 336__ $$aDissertation
000003038 502__ $$bPh.D.
000003038 502__ $$gNeuroscience
000003038 520__ $$aRecent advances in glial cell research have proven that glial cells are much more than  brain “glue,” and that glia perform numerous important functions in vertebrate and  invertebrate nervous systems. For example, glial cells are vital for maintaining brain health  after injury and in disease conditions.  In this dissertation, I present data collected during  my time in the Logan lab where we have studied how glial cells act as immune responders  in the Drosophila brain. I will discuss our current understanding of the glial cell immune response and  then present my data revealing how the evolutionarily conserved trimeric Protein  Phosphatase 4 (PP4) serine/threonine phosphatase complex is a novel member of the glial  response to nerve injury in the adult Drosophila brain.
000003038 540__ $$fCC BY
000003038 542__ $$fIn copyright - single owner
000003038 650__ $$aDrosophila$$018058
000003038 650__ $$aImmunity$$020668
000003038 650__ $$aNeuroglia$$022841
000003038 650__ $$aNeurosciences$$022870
000003038 650__ $$aPhosphoprotein Phosphatases$$024050
000003038 6531_ $$aglia
000003038 6531_ $$ainjury
000003038 6531_ $$aimmune response
000003038 691__ $$aSchool of Medicine$$041369
000003038 692__ $$aVollum Institute$$041509
000003038 7001_ $$aWinfree, Lilly$$uOregon Health and Science University$$041354$$10000-0001-7120-8536
000003038 7201_ $$aLogan, Mary$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000003038 8564_ $$94b3a29ce-6e65-4b0a-bf97-50343aaa175c$$s7679219$$uhttps://digitalcollections.ohsu.edu/record/3038/files/3868_etd.pdf$$ePublic$$21872465148bbf12e9bca17222c5b443a$$31
000003038 905__ $$a/rest/prod/5x/21/tf/68/5x21tf68v
000003038 909CO $$ooai:digitalcollections.ohsu.edu:3038$$pstudent-work
000003038 980__ $$aTheses and Dissertations