000000304 001__ 304
000000304 005__ 20260410124445.0
000000304 0247_ $$2DOI$$a10.6083/M4Q52MKW
000000304 037__ $$aETD
000000304 245__ $$aAminolevulinic acid based photodynamic therapy and diffuse optical reflectance spectroscopy
000000304 260__ $$bOregon Health and Science University
000000304 269__ $$a2008
000000304 336__ $$aDissertation
000000304 502__ $$bPh.D.
000000304 502__ $$gBiomedical Engineering
000000304 520__ $$aThis thesis explores aminolevulinic acid (ALA)–induced photodynamic therapy (PDT) as a potential treatment for equine sarcoids and canine acanthomatous epulis. ALA is a relatively inexpensive photosensitizing agent that can be administered locally, either topically or by injection, or systemically, and does not cause prolonged photosensitivity. After administration, ALA is metabolized through the heme biosynthetic pathway into protoporphyrin IX (PpIX), the active photosensitizer. Because PpIX is a naturally occurring intermediate that cells efficiently metabolize under normal conditions, treatment‑related photosensitivity is limited in duration. These characteristics make ALA‑based PDT a promising and practical therapeutic approach for veterinary tumors.
000000304 540__ $$fCC BY
000000304 542__ $$fIn copyright - single owner
000000304 650__ $$aPhotochemotherapy$$024078
000000304 650__ $$aAminolevulinic Acid$$014587
000000304 650__ $$aDogs$$018015
000000304 650__ $$aHorses$$020311
000000304 6531_ $$aphotodynamic therapy
000000304 6531_ $$aketonic acids
000000304 6531_ $$aveterinary therapeutics
000000304 691__ $$aOGI School of Science and Engineering$$041365
000000304 692__ $$aDepartment of Biomedical Engineering$$041397
000000304 7001_ $$aEngelking, Kirstin$$uOregon Health and Science University$$041354
000000304 7201_ $$aJacques, Steven$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000304 8564_ $$9b099d665-1027-49ea-8cae-cdd408508471$$s3892020$$uhttps://digitalcollections.ohsu.edu/record/304/files/304_etd.pdf$$ePublic$$29f80b95fb7f6f6b8ab52c791f13ffc61$$31
000000304 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000304 905__ $$a/rest/prod/qb/98/mf/45/qb98mf45k
000000304 909CO $$ooai:digitalcollections.ohsu.edu:304$$pstudent-work
000000304 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000304 980__ $$aTheses and Dissertations