000003047 001__ 3047
000003047 005__ 20251021081702.0
000003047 0247_ $$2DOI$$a10.6083/M447490Q
000003047 037__ $$aETD
000003047 245__ $$aThe ba/f3 transformation assay: characterization of a novel csf2rb-activating variant, and the discovery of acquired mutations in ba/f3 cells
000003047 269__ $$a2017
000003047 336__ $$aDissertation
000003047 502__ $$bPh.D.
000003047 502__ $$gCancer Biology (sunsetting)
000003047 520__ $$aIn this dissertation, the discovery of the first CSF2RB-activating human variant found in the  germline of a pediatric T-cell acute lymphoblastic leukemia patient is presented. In vitro,  CSF2RB R461C transforms Ba/F3 cells to factor-independent growth through ligand- independent activation and stabilization of CSF2RB. CSF2RB R461C increases downstream  2     activation of JAK2/STAT-5, and inhibition of JAK2 results in apoptosis, making this a  potentially actionable clinical variant.
000003047 540__ $$fCC BY
000003047 542__ $$fIn copyright - single owner
000003047 650__ $$aCell Line$$016284
000003047 650__ $$aCytokine Receptor Common beta Subunit$$037526
000003047 650__ $$aHematologic Neoplasms$$031549
000003047 650__ $$aOncogenes$$023203
000003047 691__ $$aSchool of Medicine$$041369
000003047 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000003047 7001_ $$aWatanabe-Smith, Kevin$$uOregon Health and Science University$$041354$$10000-0003-4231-8562
000003047 7201_ $$aDruker, Brian$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000003047 8564_ $$90f069b3b-8b9f-4e31-8940-98f1ebc02d56$$s4072714$$uhttps://digitalcollections.ohsu.edu/record/3047/files/3877_etd.pdf$$ePublic$$23814325cf0c84452eb2dd1d57eb14b40$$31
000003047 905__ $$a/rest/prod/3n/20/3z/35/3n203z351
000003047 909CO $$ooai:digitalcollections.ohsu.edu:3047$$pstudent-work
000003047 980__ $$aTheses and Dissertations