TY - GEN AB - Ozone is an environmental component of air pollution. It is a reactive oxygen species that acutely damages airway epithelium, increasing inflammatory cytokines, and neutrophil and eosinophil recruitment to lungs. The overall hypothesis tested in this dissertation is that ozone inhalation induces eosinophil hematopoiesis in bone marrow, and that newly divided eosinophils will ameliorate airway hyperreactivity three days later in non-sensitized and sensitized animals. AD - Oregon Health and Science University AU - Wicher, Sarah DA - 2017 DO - 10.6083/M47080J6 DO - DOI ED - Fryer, Allison ED - Jacoby, David ED - Advisor ED - Mentor ED - Mentor ID - 3049 KW - Tumor Necrosis Factor-alpha KW - Lung KW - Airway Management KW - Eosinophils KW - Ozone L1 - https://digitalcollections.ohsu.edu/record/3049/files/3879_etd.pdf L2 - https://digitalcollections.ohsu.edu/record/3049/files/3879_etd.pdf L4 - https://digitalcollections.ohsu.edu/record/3049/files/3879_etd.pdf LK - https://digitalcollections.ohsu.edu/record/3049/files/3879_etd.pdf N2 - Ozone is an environmental component of air pollution. It is a reactive oxygen species that acutely damages airway epithelium, increasing inflammatory cytokines, and neutrophil and eosinophil recruitment to lungs. The overall hypothesis tested in this dissertation is that ozone inhalation induces eosinophil hematopoiesis in bone marrow, and that newly divided eosinophils will ameliorate airway hyperreactivity three days later in non-sensitized and sensitized animals. PB - Oregon Health and Science University PY - 2017 T1 - Ozone induced airway hyperreactivity and eosinophil hematopoiesis depends on tumor necrosis factor-alpha and sensitization status in guinea pigs TI - Ozone induced airway hyperreactivity and eosinophil hematopoiesis depends on tumor necrosis factor-alpha and sensitization status in guinea pigs UR - https://digitalcollections.ohsu.edu/record/3049/files/3879_etd.pdf Y1 - 2017 ER -