000003049 001__ 3049
000003049 005__ 20251021123145.0
000003049 0247_ $$2DOI$$a10.6083/M47080J6
000003049 037__ $$aETD
000003049 245__ $$aOzone induced airway hyperreactivity and eosinophil hematopoiesis depends on tumor necrosis factor-alpha and sensitization status in guinea pigs
000003049 260__ $$bOregon Health and Science University
000003049 269__ $$a2017
000003049 336__ $$aDissertation
000003049 502__ $$bPh.D.
000003049 502__ $$gPhysiology & Pharmacology (sunsetting)
000003049 520__ $$aOzone is an environmental component of air pollution. It is a reactive oxygen species  that acutely damages airway epithelium, increasing inflammatory cytokines, and  neutrophil and eosinophil recruitment to lungs. The overall hypothesis tested in this  dissertation is that ozone inhalation induces eosinophil hematopoiesis in bone  marrow, and that newly divided eosinophils will ameliorate airway hyperreactivity  three days later in non-sensitized and sensitized animals.
000003049 540__ $$fCC BY
000003049 542__ $$fIn copyright - single owner
000003049 650__ $$aTumor Necrosis Factor-alpha$$027502
000003049 650__ $$aLung$$021644
000003049 650__ $$aAirway Management$$039092
000003049 650__ $$aEosinophils$$018511
000003049 650__ $$aOzone$$023458
000003049 691__ $$aSchool of Medicine$$041369
000003049 692__ $$aDepartment of Physiology and Pharmacology$$041442
000003049 7001_ $$aWicher, Sarah$$uOregon Health and Science University$$041354$$10000-0002-0079-7924
000003049 7201_ $$aFryer, Allison$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000003049 7201_ $$aJacoby, David$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000003049 8564_ $$91c461afe-b9e6-4a35-8ff0-3076ebd82f67$$s74223547$$uhttps://digitalcollections.ohsu.edu/record/3049/files/3879_etd.pdf$$ePublic$$2f6b13c4c1447840780c52c00f3cfd041$$31
000003049 905__ $$a/rest/prod/c2/47/ds/37/c247ds37c
000003049 909CO $$ooai:digitalcollections.ohsu.edu:3049$$pstudent-work
000003049 980__ $$aTheses and Dissertations