@article{ETD,
      recid = {3051},
      author = {Juarez, Eleonora},
      title = {Cellular pathways in the repair and tolerance of  formaldehyde-induced DNA damage},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2016},
      number = {ETD},
      abstract = {Formaldehyde  is  a  highly  reactive  compound  produced   extensively  worldwide.  People  are  exposed  to   formaldehyde  in  both  industrial  and  occupational   settings,  and  environmentally  via  off-gassing  of   vehicle  exhaust,  cigarette  smoke,  and  home  production   materials.  Formaldehyde  has  been  implicated  extensively in human carcinogenicity studies, and thus is  classified as  a class I human DNA carcinogen. Formaldehyde  has been shown to have severe  detrimental effects on  cellular processes, likely due to induction of its  predominant  DNA lesion, DNA-protein crosslinks. This  covalent linkage of proteins to DNA has  been demonstrated  to occur with a plethora of proteins, implicated in a wide  variety  of  cellular  process.  Consequently,  studies   have  identified  several  DNA  repair  pathways  that   play  a  role  in  mitigating  cytotoxicity  and   genotoxicity  after  formaldehyde exposure. In this study,  we choose to further define and reconcile  discrepancies in  the literature by using a high-throughput systems approach  to  discern  the  conserved  pathways  necessary  for   survival  following  chronic  formaldehyde exposure, across  cell type and species.},
      url = {http://digitalcollections.ohsu.edu/record/3051},
      doi = {https://doi.org/10.6083/M4ST7NZ9},
}