TY  - GEN
AB  - Formaldehyde  is  a  highly  reactive  compound  produced  extensively  worldwide.  People  are  exposed  to  formaldehyde  in  both  industrial  and  occupational  settings,  and  environmentally  via  off-gassing  of  vehicle  exhaust,  cigarette  smoke,  and  home  production  materials.  Formaldehyde  has  been  implicated extensively in human carcinogenicity studies, and thus is classified as  a class I human DNA carcinogen. Formaldehyde has been shown to have severe  detrimental effects on cellular processes, likely due to induction of its predominant  DNA lesion, DNA-protein crosslinks. This covalent linkage of proteins to DNA has  been demonstrated to occur with a plethora of proteins, implicated in a wide variety  of  cellular  process.  Consequently,  studies  have  identified  several  DNA  repair  pathways  that  play  a  role  in  mitigating  cytotoxicity  and  genotoxicity  after  formaldehyde exposure. In this study, we choose to further define and reconcile  discrepancies in the literature by using a high-throughput systems approach to  discern  the  conserved  pathways  necessary  for  survival  following  chronic  formaldehyde exposure, across cell type and species.
AD  - Oregon Health and Science University
AU  - Juarez, Eleonora
DA  - 2016
DO  - 10.6083/M4ST7NZ9
DO  - DOI
ID  - 3051
KW  - Carcinogens
KW  - DNA Repair
KW  - Formaldehyde
KW  - Systems Analysis
KW  - Cell Cycle
L1  - https://digitalcollections.ohsu.edu/record/3051/files/3881_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/3051/files/3881_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/3051/files/3881_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/3051/files/3881_etd.pdf
N2  - Formaldehyde  is  a  highly  reactive  compound  produced  extensively  worldwide.  People  are  exposed  to  formaldehyde  in  both  industrial  and  occupational  settings,  and  environmentally  via  off-gassing  of  vehicle  exhaust,  cigarette  smoke,  and  home  production  materials.  Formaldehyde  has  been  implicated extensively in human carcinogenicity studies, and thus is classified as  a class I human DNA carcinogen. Formaldehyde has been shown to have severe  detrimental effects on cellular processes, likely due to induction of its predominant  DNA lesion, DNA-protein crosslinks. This covalent linkage of proteins to DNA has  been demonstrated to occur with a plethora of proteins, implicated in a wide variety  of  cellular  process.  Consequently,  studies  have  identified  several  DNA  repair  pathways  that  play  a  role  in  mitigating  cytotoxicity  and  genotoxicity  after  formaldehyde exposure. In this study, we choose to further define and reconcile  discrepancies in the literature by using a high-throughput systems approach to  discern  the  conserved  pathways  necessary  for  survival  following  chronic  formaldehyde exposure, across cell type and species.
PB  - Oregon Health and Science University
PY  - 2016
T1  - Cellular pathways in the repair and tolerance of formaldehyde-induced DNA damage
TI  - Cellular pathways in the repair and tolerance of formaldehyde-induced DNA damage
UR  - https://digitalcollections.ohsu.edu/record/3051/files/3881_etd.pdf
Y1  - 2016
ER  -