TY  - GEN
AB  - A large body of evidence shows that prolonged stress or even a single traumatic experience can lead to neurobiological and behavioral changes that are persistent. These changes have many deleterious long-term consequences and can lead to the development of post-traumatic stress disorder (PTSD). PTSD is associated with epigenetic changes that result in altered gene expression and subsequent protein synthesis. These epigenetic changes may account for the development of the disease  itself in the form of exaggerated fear responses to neutral or mild stimuli and may render individuals more susceptible to the use and subsequent dependence on drugs of abuse. Substance use disorders (SUDs) similarly evoke persistent changes in gene  expression that are mediated by epigenetic mechanisms. Because both PTSD and SUDs involve a memory component and an inability to extinguish unwanted behavioral responses, similar epigenetic changes may underlie long-term memory effects in both  anxiety disorders and addiction.This dissertation work focuses on this interaction, emphasizing how an epigenetic approach to memory suppression may be a useful avenue to pursue in designing treatments for disorders that involve failures of inhibition, such as PTSD and substance abuse.
AD  - Oregon Health and Science University
AU  - Pizzimenti, Christie
DA  - 2018
DO  - 10.6083/M4PC31XG
DO  - DOI
ED  - Lattal, Matthew
ED  - Advisor
ED  - Mentor
ID  - 3058
KW  - Methamphetamine
KW  - Fear
KW  - Epigenesis, Genetic
KW  - Memory, Long-Term
KW  - Gene Expression
KW  - Anxiety Disorders
KW  - Self Administration
KW  - Stress Disorders, Post-Traumatic
KW  - Drug-Seeking Behavior
KW  - Substance-Related Disorders
L1  - https://digitalcollections.ohsu.edu/record/3058/files/3991_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/3058/files/3991_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/3058/files/3991_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/3058/files/3991_etd.pdf
N2  - A large body of evidence shows that prolonged stress or even a single traumatic experience can lead to neurobiological and behavioral changes that are persistent. These changes have many deleterious long-term consequences and can lead to the development of post-traumatic stress disorder (PTSD). PTSD is associated with epigenetic changes that result in altered gene expression and subsequent protein synthesis. These epigenetic changes may account for the development of the disease  itself in the form of exaggerated fear responses to neutral or mild stimuli and may render individuals more susceptible to the use and subsequent dependence on drugs of abuse. Substance use disorders (SUDs) similarly evoke persistent changes in gene  expression that are mediated by epigenetic mechanisms. Because both PTSD and SUDs involve a memory component and an inability to extinguish unwanted behavioral responses, similar epigenetic changes may underlie long-term memory effects in both  anxiety disorders and addiction.This dissertation work focuses on this interaction, emphasizing how an epigenetic approach to memory suppression may be a useful avenue to pursue in designing treatments for disorders that involve failures of inhibition, such as PTSD and substance abuse.
PB  - Oregon Health and Science University
PY  - 2018
T1  - Exploring the use of histone deacetylase inhibitors in treating rodent models of post-traumatic stress disorder and addiction
TI  - Exploring the use of histone deacetylase inhibitors in treating rodent models of post-traumatic stress disorder and addiction
UR  - https://digitalcollections.ohsu.edu/record/3058/files/3991_etd.pdf
Y1  - 2018
ER  -