000003058 001__ 3058 000003058 005__ 20251013113718.0 000003058 0247_ $$2DOI$$a10.6083/M4PC31XG 000003058 037__ $$aETD 000003058 245__ $$aExploring the use of histone deacetylase inhibitors in treating rodent models of post-traumatic stress disorder and addiction 000003058 260__ $$bOregon Health and Science University 000003058 269__ $$a2018 000003058 336__ $$aDissertation 000003058 502__ $$bPh.D. 000003058 520__ $$aA large body of evidence shows that prolonged stress or even a single traumatic experience can lead to neurobiological and behavioral changes that are persistent. These changes have many deleterious long-term consequences and can lead to the development of post-traumatic stress disorder (PTSD). PTSD is associated with epigenetic changes that result in altered gene expression and subsequent protein synthesis. These epigenetic changes may account for the development of the disease itself in the form of exaggerated fear responses to neutral or mild stimuli and may render individuals more susceptible to the use and subsequent dependence on drugs of abuse. Substance use disorders (SUDs) similarly evoke persistent changes in gene expression that are mediated by epigenetic mechanisms. Because both PTSD and SUDs involve a memory component and an inability to extinguish unwanted behavioral responses, similar epigenetic changes may underlie long-term memory effects in both anxiety disorders and addiction.This dissertation work focuses on this interaction, emphasizing how an epigenetic approach to memory suppression may be a useful avenue to pursue in designing treatments for disorders that involve failures of inhibition, such as PTSD and substance abuse. 000003058 540__ $$fCC BY 000003058 542__ $$fIn copyright - single owner 000003058 650__ $$aMethamphetamine$$022135 000003058 650__ $$aFear$$018921 000003058 650__ $$aEpigenesis, Genetic$$035405 000003058 650__ $$aMemory, Long-Term$$038947 000003058 650__ $$aGene Expression$$028717 000003058 650__ $$aAnxiety Disorders$$014947 000003058 650__ $$aSelf Administration$$025838 000003058 650__ $$aStress Disorders, Post-Traumatic$$026468 000003058 650__ $$aDrug-Seeking Behavior$$039458 000003058 650__ $$aSubstance-Related Disorders$$032029 000003058 691__ $$aSchool of Medicine$$041369 000003058 692__ $$aDepartment of Behavioral Neuroscience$$041394 000003058 7001_ $$aPizzimenti, Christie$$uOregon Health and Science University$$041354 000003058 7201_ $$aLattal, Matthew$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor 000003058 8564_ $$9b43b13d6-4094-422c-ba64-eaa11c4a8a92$$s2593013$$uhttps://digitalcollections.ohsu.edu/record/3058/files/3991_etd.pdf$$ePublic$$2fce59a703f057d7f89c1cc44e2c54ce9$$31 000003058 905__ $$a/rest/prod/sj/13/92/22/sj139222d 000003058 909CO $$ooai:digitalcollections.ohsu.edu:3058$$pstudent-work 000003058 980__ $$aTheses and Dissertations