000003067 001__ 3067 000003067 005__ 20251010123436.0 000003067 0247_ $$2DOI$$a10.6083/M4CR5SXB 000003067 037__ $$aETD 000003067 245__ $$aNanoparticle based RNAi therapeutic to overcome intrinsic and acquired resistance in HER2+ breast cancer 000003067 260__ $$bOregon Health and Science University 000003067 269__ $$a2018 000003067 336__ $$aDissertation 000003067 502__ $$bPh.D. 000003067 502__ $$gBiomedical Engineering 000003067 520__ $$aThe HER2 receptor tyrosine kinase is overexpressed in approximately 20% of all breast cancers and is a poor prognostic indicator. Hyperactive HER2 signaling leads to aggressive tumor growth, metastasis, and resistance to traditional chemotherapy. The use of HER2 targeted therapies such as trastuzumab and lapatinib has dramatically prolonged survival compared to chemotherapy treatment alone. Unfortunately, a significant number of patients do not respond to these therapies while others will eventually relapse, prompting the need for better alternatives. We hypothesized that the ablation of HER2 protein by RNA interference would be a more effective and durable therapeutic approach. 000003067 540__ $$fCC BY 000003067 542__ $$fIn copyright - single owner 000003067 650__ $$aNeoplasm Recurrence, Local$$022753 000003067 650__ $$aBreast Neoplasms$$015809 000003067 650__ $$aNanoparticles$$037592 000003067 650__ $$aReceptor, ErbB-2$$031038 000003067 650__ $$aRNA Interference$$034586 000003067 650__ $$aRNA, Small Interfering$$034596 000003067 6531_ $$aher2 000003067 691__ $$aSchool of Medicine$$041369 000003067 692__ $$aDepartment of Biomedical Engineering$$041397 000003067 7001_ $$aGu, Shenda$$uOregon Health and Science University$$041354$$10000-0003-2271-0524 000003067 7201_ $$aYantasee, Wassana$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor 000003067 8564_ $$9d8c3bc72-8782-4e69-b293-298da0534b81$$s3740806$$uhttps://digitalcollections.ohsu.edu/record/3067/files/4000_etd.pdf$$ePublic$$21b4e905af1121240f878e97e6aebc5b7$$31 000003067 905__ $$a/rest/prod/b2/77/3v/87/b2773v87q 000003067 909CO $$ooai:digitalcollections.ohsu.edu:3067$$pstudent-work 000003067 980__ $$aTheses and Dissertations