TY  - THES
AB  - Water quality impacts both human and ecosystem health. Many pharmaceuticals and  personal care products are considered contaminants of emerging concern (CEC) due to  their bioactive properties. Among these, metformin—the most commonly prescribed drug  for treatment of type 2 diabetes—has been reported at high concentrations (μg L-1) in  stream, lake, and estuary surface waters in the United States. However, a propensity for  broad-scale CEC surveys has prevented seasonal and spatial monitoring of metformin in  river systems. Moreover, the effect of metformin in river food webs remains poorly  explored, despite its known action on conserved eukaryotic enzymes  (AMPK/SnRK1/SNF1). This project comprised the first spatiotemporal characterization of metformin in a high-discharge river system and examined the effects of metformin on  aquatic primary producers.
AD  - Oregon Health and Science University
AU  - Cummings, Brittany
DA  - 2018
DO  - 10.6083/M44749FJ
DO  - DOI
ED  - Needoba, Jacob
ED  - Peterson, Tawnya
ED  - Co-Mentor
ED  - Advisor
ED  - Mentor
ID  - 3069
KW  - Metformin
KW  - Water Quality
KW  - Rivers
KW  - Phytoplankton
KW  - Prescription Drugs
KW  - Lakes
KW  - Estuaries
KW  - Ecosystem
KW  - Diabetes Mellitus, Type 2
KW  - algae contaminant
L1  - https://digitalcollections.ohsu.edu/record/3069/files/4002_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/3069/files/4002_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/3069/files/4002_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/3069/files/4002_etd.pdf
N2  - Water quality impacts both human and ecosystem health. Many pharmaceuticals and  personal care products are considered contaminants of emerging concern (CEC) due to  their bioactive properties. Among these, metformin—the most commonly prescribed drug  for treatment of type 2 diabetes—has been reported at high concentrations (μg L-1) in  stream, lake, and estuary surface waters in the United States. However, a propensity for  broad-scale CEC surveys has prevented seasonal and spatial monitoring of metformin in  river systems. Moreover, the effect of metformin in river food webs remains poorly  explored, despite its known action on conserved eukaryotic enzymes  (AMPK/SnRK1/SNF1). This project comprised the first spatiotemporal characterization of metformin in a high-discharge river system and examined the effects of metformin on  aquatic primary producers.
PY  - 2018
T1  - Spatiotemporal distribution of the anti-diabetic drug, metformin, in the Lower Columbia River and its effect on phytoplankton growth
TI  - Spatiotemporal distribution of the anti-diabetic drug, metformin, in the Lower Columbia River and its effect on phytoplankton growth
UR  - https://digitalcollections.ohsu.edu/record/3069/files/4002_etd.pdf
Y1  - 2018
ER  -