000003069 001__ 3069
000003069 005__ 20251009162532.0
000003069 0247_ $$2DOI$$a10.6083/M44749FJ
000003069 037__ $$aETD
000003069 245__ $$aSpatiotemporal distribution of the anti-diabetic drug, metformin, in the Lower Columbia River and its effect on phytoplankton growth
000003069 269__ $$a2018
000003069 336__ $$aThesis
000003069 502__ $$bM.S.
000003069 520__ $$aWater quality impacts both human and ecosystem health. Many pharmaceuticals and  personal care products are considered contaminants of emerging concern (CEC) due to  their bioactive properties. Among these, metformin—the most commonly prescribed drug  for treatment of type 2 diabetes—has been reported at high concentrations (μg L-1) in  stream, lake, and estuary surface waters in the United States. However, a propensity for  broad-scale CEC surveys has prevented seasonal and spatial monitoring of metformin in  river systems. Moreover, the effect of metformin in river food webs remains poorly  explored, despite its known action on conserved eukaryotic enzymes  (AMPK/SnRK1/SNF1). This project comprised the first spatiotemporal characterization of metformin in a high-discharge river system and examined the effects of metformin on  aquatic primary producers.
000003069 540__ $$fCC BY
000003069 542__ $$fIn copyright - single owner
000003069 650__ $$aMetformin$$022128
000003069 650__ $$aWater Quality$$039802
000003069 650__ $$aRivers$$035650
000003069 650__ $$aPhytoplankton$$024135
000003069 650__ $$aPrescription Drugs$$038366
000003069 650__ $$aLakes$$039694
000003069 650__ $$aEstuaries$$040221
000003069 650__ $$aEcosystem$$030218
000003069 650__ $$aDiabetes Mellitus, Type 2$$017675
000003069 651__ $$aUnited States--Columbia River$$044429
000003069 6531_ $$aalgae contaminant
000003069 691__ $$aSchool of Medicine$$041369
000003069 692__ $$aInstitute of Environmental Health$$041473
000003069 7001_ $$aCummings, Brittany$$uOregon Health and Science University$$041354$$10000-0003-0963-6526
000003069 7201_ $$aNeedoba, Jacob$$uOregon Health and Science University$$041354$$7Personal$$eCo-Mentor
000003069 7201_ $$aPeterson, Tawnya$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000003069 8564_ $$9f4a055eb-be5c-472a-a628-6ec77ae6b44d$$s4526135$$uhttps://digitalcollections.ohsu.edu/record/3069/files/4002_etd.pdf$$ePublic$$2abc44da931ad9e521b4e38a7a221a60c$$31
000003069 905__ $$a/rest/prod/h1/28/nd/94/h128nd94x
000003069 909CO $$ooai:digitalcollections.ohsu.edu:3069$$pstudent-work
000003069 980__ $$aTheses and Dissertations