TY  - GEN
AB  - Drug-Induced Ototoxicity is a widespread global problem occurring as a side effect of otherwise effective therapies for conditions such as bacterial sepsis (aminoglycosides) and cancers (platinum-based chemotherapy). It is becoming clear that having the conditions requiring these drugs itself puts the patient at increased risk for acquiring life-long hearing loss. This apparent clinical paradox places the provider in difficult position where treating the life-threatening condition will most likely result in poor hearing outcomes. Since these ototoxic therapies are both life-saving and economically viable, understanding the mechanisms of hearing loss and developing effective strategies to preserve hearing during treatment for life-threatening illness has the potential to greatly enhance the quality of life in vulnerable patient populations.
AD  - Oregon Health and Science University
AU  - Urdang, Zachary
DA  - 2018
DO  - 10.6083/M4N29WH9
DO  - DOI
ID  - 3073
KW  - Hearing
KW  - Cochlea
KW  - Inflammation
KW  - toxicity
L1  - https://digitalcollections.ohsu.edu/record/3073/files/4006_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/3073/files/4006_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/3073/files/4006_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/3073/files/4006_etd.pdf
N2  - Drug-Induced Ototoxicity is a widespread global problem occurring as a side effect of otherwise effective therapies for conditions such as bacterial sepsis (aminoglycosides) and cancers (platinum-based chemotherapy). It is becoming clear that having the conditions requiring these drugs itself puts the patient at increased risk for acquiring life-long hearing loss. This apparent clinical paradox places the provider in difficult position where treating the life-threatening condition will most likely result in poor hearing outcomes. Since these ototoxic therapies are both life-saving and economically viable, understanding the mechanisms of hearing loss and developing effective strategies to preserve hearing during treatment for life-threatening illness has the potential to greatly enhance the quality of life in vulnerable patient populations.
PB  - Oregon Health and Science University
PY  - 2018
T1  - Toll-like receptor four and neutrophil contributions to endotoxemia - enhanced aminoglycoside ototoxicity
TI  - Toll-like receptor four and neutrophil contributions to endotoxemia - enhanced aminoglycoside ototoxicity
UR  - https://digitalcollections.ohsu.edu/record/3073/files/4006_etd.pdf
Y1  - 2018
ER  -